Physicochemical Property Correlations with Ionization Efficiency in Capillary Vibrating Sharp-Edge Spray Ionization (cVSSI).
Physicochemical Property Correlations with Ionization Efficiency in Capillary Vibrating Sharp-Edge Spray Ionization (cVSSI).
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DOI：
10.1021/jasms.0c00100
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发表时间：
2021-01-06
影响因子：
3.2
通讯作者：
Valentine SJ
中科院分区：
文献类型：
--
作者：
Jayasundara KU;Li C;DeBastiani A;Sharif D;Li P;Valentine SJ
用质谱仪研究了无场和场使能毛细管振动尖边喷雾电离(CVSSI)中三种分子化学性质对电离效率的相对贡献。记录了模型化合物在每种操作电离模式下以及水和非水(甲醇)溶剂系统的离子强度。多元回归分析表明，对于无场cVSSI，离子强度主要与水溶液和甲醇溶液的碱解离常数(PKB)和质子亲和力(PA)的对数有关。相比之下，对于使用水溶液的场使能cVSSI，与离子强度相关的主导因素是分配系数的对数(LogP)。在较小程度上，这也可以在甲醇溶液中观察到。对于ESI，PKB是与来自甲醇和水溶液的离子信号水平相关的主导因素。这些结果得到了在使用不同cVSSI发射器尖端的两个不同质谱计上进行的研究的支持。ESI中离子强度与pKB的关系得到了多项研究的支持；然而，随着cVSSI的加入而向其他化学性质的转变表明，一种不同的(或组合的)电离机制(S)可能对这些电离模式起作用。根据不同的ESI机制，对这些结果进行了简要的讨论。
The relative contributions to ionization efficiency by three molecular chemical properties have been examined for field-free and field-enabled capillary Vibrating Sharp-edge Spray Ionization (cVSSI) using mass spectrometry (MS) analysis. Ion intensities have been recorded for model compounds under each operational ionization mode as well as for aqueous and non-aqueous (methanol) solvent systems. Multiple regression analysis suggests that for field-free cVSSI, ion intensity is mostly associated with log of the base dissociation constant (pKb) and proton affinity (PA) for both aqueous and methanol solutions. Comparatively, for field-enabled cVSSI using aqueous solutions, the dominant factor correlated with ion intensity is log of the partition coefficient (log P). To a lesser degree this is observed for methanol solutions as well. For ESI, pKb is the dominant factor associated with ion signal levels from methanol and aqueous solutions. These results are supported by studies conducted on two different mass spectrometers employing different cVSSI emitter tips. The relationship of ion intensity and pKb in ESI is supported by multiple studies; however, the shift to other chemical properties with the addition of cVSSI suggests the possibility that a different (or combinations of) ionization mechanism(s) may be operative for these ionization modes. These results are briefly considered in light of the different ESI mechanisms.
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影响因子：
7.4
作者：
Cody, RB;Laramée, JA;Durst, HD
通讯作者：
Durst, HD
DOI：
10.1007/s13361-019-02140-7
发表时间：
2019-06-01
影响因子：
3.2
作者：
He, Liqing;Wei, Xiaoli;Zhang, Xiang
通讯作者：
Zhang, Xiang
DOI：
10.1016/1044-0305(94)85001-1
发表时间：
1994-07-01
影响因子：
3.2
作者：
EMMETT, MR;CAPRIOLI, RM
通讯作者：
CAPRIOLI, RM
影响因子：
15
作者：
GROSS, DS;WILLIAMS, ER
通讯作者：
WILLIAMS, ER
DOI：
10.1016/j.jasms.2008.01.003
发表时间：
2008-05-01
影响因子：
3.2
作者：
Ehrmann, Brandie M.;Henriksen, Trine;Cech, Nadja B.
通讯作者：
Cech, Nadja B.