The significant prognostic value of ZEB1-AS1 up-regulation in patients with cancer.
The significant prognostic value of ZEB1-AS1 up-regulation in patients with cancer.
复制标题
ZEB1-AS1上调对癌症患者的显着预后价值
DOI：
10.7150/jca.25264
复制
发表时间：
2018
影响因子：
3.9
通讯作者：
Shao S
中科院分区：
文献类型：
--
作者：
Ni Y;Fang J;Zhu L;Jiang H;Liu Y;Miao R;Shao C;Shao S
Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is a long non-coding RNA, which has found to unregulated in various kinds of cancer. This meta-analysis was conducted to demonstrate the association between ZEB1-AS1 expression levels and clinical outcome or prognosis of cancer patients.10 studies with 783 cancer patients were included in this meta-analysis by retrieving 5 databases (PubMed Central, EMBASE, Cochrane Library, Wiley Online Library and Medline).The result showed that overexpression of ZEB1-AS1 is significantly correlated with poor OS (Hazard ratio, HR=2.45, 95% confidence interval, CI: 1.89-3.16). ZEB1-AS1 expression levels were also associated with clinicopathological parameters including lymph node metastasis (Yes vs. No; OR=4.00, 95%CI: 2.23-7.17, P<0.00001), histologic differentiation (Moderate + poor vs. Well; OR=2.72, 95% CI: 1.69-4.37, p<0.0001), tumor metastasis and invasion (Yes vs. No; OR =2.52, 95%CI: 1.12-5.68, P=0.03) and TNM stage (III+IV vs. I+II; OR=2.76, 95 %CI 1.46-5.21, P=0.002). However, ZEB1-AS1 expression was not significantly associated with patients' gender (Male vs. Female; OR=1.20, 95% CI: 0.87-1.66; P=0.27).This meta-analysis indicated the potential value of ZEB1-AS1 as a biomarker for predicting a poor prognosis in patients with cancer.
登录
查看更多内容
长非编码RNA ZEB1-AS1表观遗传调节前列腺癌中ZEB1及下游分子的表达
影响因子：
37.3
作者：
Su W;Xu M;Chen X;Chen N;Gong J;Nie L;Li L;Li X;Zhang M;Zhou Q
通讯作者：
Zhou Q
影响因子：
254.7
作者：
Siegel, Rebecca;Ma, Jiemin;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
2.5
作者：
Tierney JF;Stewart LA;Ghersi D;Burdett S;Sydes MR
通讯作者：
Sydes MR
影响因子：
--
作者：
Fang J;Qiao F;Tu J;Xu J;Ding F;Liu Y;Akuo BA;Hu J;Shao S
通讯作者：
Shao S
影响因子：
2.2
作者：
DerSimonian R;Laird N
通讯作者：
Laird N