High expression of long non-coding RNA NEAT1 indicates poor prognosis of human cancer.
High expression of long non-coding RNA NEAT1 indicates poor prognosis of human cancer.
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DOI：
10.18632/oncotarget.17439
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发表时间：
2017-07-11
期刊：
影响因子：
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通讯作者：
Shao S
中科院分区：
文献类型：
--
作者：
Fang J;Qiao F;Tu J;Xu J;Ding F;Liu Y;Akuo BA;Hu J;Shao S
核旁斑点装配转录本1（NEAT 1）是一种长链非编码RNA。许多研究已经报道NEAT 1在多种人类癌症中发挥关键的致癌作用并促进肿瘤发生。NEAT 1高表达与癌症患者的预后不良相关。这项荟萃分析旨在评估NEAT 1水平与癌症患者生存时间之间的关联。总生存期（OS）是主要终点。来自5个数据库（PubMed、EMBASE、科克伦图书馆、Wiley在线图书馆和Medline）的13篇出版物（1，496例癌症患者）符合本荟萃分析的标准。分析结果显示，NEAT 1在人类癌症中的表达与OS显著相关（风险比[HR]=1.53，95%置信区间[CI]：1.39-1.68），包括消化系统肿瘤（HR=1.54，95% CI：1.37-1.73）和呼吸道癌（HR=1.44，95% CI：1.11-1.85）。结果还表明NEAT 1表达与肿瘤大小高度相关（>3 cm vs. ≤3 cm;比值比[OR]=2.51，95% CI：1.27-4.99; p=0.009），TNM分期（III+IV vs. I+II; OR=4.17，95%CI：2.42-7.18; p=0.00001）和远处转移（OR=2.73，95%CI：1.28-5.79; p=0.01）。但与分化程度（低分化vs高分化+中等分化，OR=1.45，95% CI：0.72-2.91）和淋巴结转移（OR=1.39，95% CI：0.54-3.60）无显著相关性。这项荟萃分析表明，NEAT 1表达可能是预测癌症患者预后不良的有用生物标志物。
The nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA. Many studies have reported that NEAT1 plays critical oncogenic roles and facilitates tumorigenesis of various human cancers. High NEAT1 expression is associated with a poor prognosis in cancer patients. This meta-analysis was conducted to assess the association between NEAT1 levels and survival times of cancer patients. Overall survival (OS) was the primary endpoint. Thirteen publications with 1,496 cancer patients from 5 databases (PubMed, EMBASE, Cochrane Library, Wiley Online Library, and Medline) met the criteria for this meta-analysis. Results of the analysis showed that NEAT1 expression in human cancer was significantly associated with OS (hazard ratio [HR]=1.53, 95% confidence interval [CI]: 1.39–1.68), including digestive system tumor (HR=1.54, 95% CI: 1.37–1.73) and respiratory carcinomas (HR=1.44, 95% CI: 1.11–1.85). The results also indicated that NEAT1 expression was highly associated with tumor size (>3 cm vs. ≤3 cm; odds ratio [OR]=2.51, 95% CI: 1.27–4.99; p=0.009), TNM stage (III+IV vs. I+II; OR=4.17, 95% CI: 2.42–7.18; p=0.00001), and distant metastasis (OR=2.73, 95% CI: 1.28–5.79; p=0.01). However, there was no significant association with differentiation (poor vs. well + moderate, OR=1.45, 95% CI: 0.72–2.91) and lymph node metastasis (OR=1.39, 95% CI: 0.54–3.60). This meta-analysis showed that NEAT1 expression may be a useful biomarker for predicting a poor prognosis in patients with cancer.
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NEAT 表达与结直肠癌肿瘤复发和不良预后相关
影响因子：
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作者：
Li Y;Li Y;Chen W;He F;Tan Z;Zheng J;Wang W;Zhao Q;Li J
通讯作者：
Li J
影响因子：
2.5
作者：
Tierney JF;Stewart LA;Ghersi D;Burdett S;Sydes MR
通讯作者：
Sydes MR
影响因子：
--
作者：
Lu, Yaoyong;Li, Tao;Liao, Rongwei
通讯作者：
Liao, Rongwei
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
11.4
作者：
Blume, C. J.;Hotz-Wagenblatt, A.;Zenz, T.
通讯作者：
Zenz, T.