MULTIPLE EQUILIBRIA AND MAINTENANCE OF ADDITIVE GENETIC VARIANCE IN A MODEL OF PLEIOTROPY
MULTIPLE EQUILIBRIA AND MAINTENANCE OF ADDITIVE GENETIC VARIANCE IN A MODEL OF PLEIOTROPY
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多效性模型中的多重平衡与加性遗传变异的维持
DOI：
10.1111/j.1558-5646.1990.tb05222.x
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发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
C. Hom
中科院分区：
文献类型：
--
作者：
A. Hastings;C. Hom
我们描述了一个多位点模型，采用多效性稳定选择大量的字符。我们发现了许多不同的稳定平衡与不同水平的多态性和加性遗传变异。结果支持赖特的概念，一个复杂的自适应表面与许多不同高度的峰。该模型假设等位基因对性状的贡献是加性的。我们通过首先考虑双位点模型来分析多位点模型。双基因座模型关键取决于具有不同效应的基因座，以及具有不是完全杂合个体的最佳表型。不同基因座的影响只需相差不到两倍即可。对于多位点多性状模型，我们假设完全杂合的个体不具有最佳表型。通过将注意力限制在双等位基因模型上，我们还假设没有等位基因可以在所有可能的方向组合中影响所有字符。
We describe a multilocus model that incorporates pleiotropic stabilizing selection on a large number of characters. We find many different stable equilibria with different levels of polymorphism and additive genetic variability. The results lend support to Wright's concept of a complex adaptive surface with many peaks of different heights. The model assumes that alleles contribute additively to the characters. We analyze the multilocus model by first considering a two‐locus model. The two‐locus model depends critically on having loci of different effect and on having the optimum phenotype not be that of a completely heterozygous individual. The effects of different loci need to differ only by less than a factor of two. For the multilocus, multicharacter model, we assume that completely heterozygous individuals do not have the optimum phenotype. By restricting attention to a two‐allele model, we also assume that there are no alleles that can affect all characters in all possible combinations of directions.
多效性稳定选择将多态性基因座的数量限制为至多字符的数量。
影响因子：
3.3
作者：
Hastings,A;Hom,CL
通讯作者：
Hom,CL
在稳定选择下维持加性变异：两个数量性状的多效性的双基因座模型。
影响因子：
3.3
作者：
Gimelfarb,A
通讯作者：
Gimelfarb,A