Pleiotropic stabilizing selection limits the number of polymorphic loci to at most the number of characters.

Pleiotropic stabilizing selection limits the number of polymorphic loci to at most the number of characters.
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多效性稳定选择将多态性基因座的数量限制为至多字符的数量。

DOI:
10.1093/genetics/122.2.459
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发表时间:
1989
期刊:
影响因子:
3.3
通讯作者:
Hom,CL
Hom,CL
中科院分区:
生物学2区
文献类型:
--
作者:
Hastings,A;Hom,CL

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我们证明了在一个包含弱高斯稳定选择的模型中,在n个加性确定的性状上,在稳定平衡下最多有n个位点是多态的。在高斯选择方案中,字符数被定义为独立分量的个数。我们还假设连锁平衡,并且要么位点数量足够大,种群中的表型分布可以近似为多元高斯分布,要么选择足够弱,种群的平均适应度可以仅使用种群中性状的平均值和方差来近似。我们的结果似乎排除了拮抗多效性而不上位性是在统一环境中维持加性遗传变异的主要力量。然而,如果一个性状在不同的环境中对应不同的性状,并且不同环境的数量超过影响该性状的多态位点的数量,则它们与基因型-环境相互作用对变异的维持是一致的。
We demonstrate that, in a model incorporating weak Gaussian stabilizing selection on n additively determined characters, at most n loci are polymorphic at a stable equilibrium. The number of characters is defined to be the number of independent components in the Gaussian selection scheme. We also assume linkage equilibrium, and that either the number of loci is large enough that the phenotypic distribution in the population can be approximated as multivariate Gaussian or that selection is weak enough that the mean fitness of the population can be approximated using only the mean and the variance of the characters in the population. Our results appear to rule out antagonistic pleiotropy without epistasis as a major force in maintaining additive genetic variation in a uniform environment. However, they are consistent with the maintenance of variability by genotype-environment interaction if a trait in different environments corresponds to different characters and the number of different environments exceeds the number of polymorphic loci that affect the trait.
多效性过度显性和多基因性状遗传变异的维持。
DOI: 10.1093/genetics/107.2.321
发表时间: 1984
期刊: Genetics
影响因子: 3.3
作者:
J. Gillespie
通讯作者: J. Gillespie
在稳定选择下维持加性变异:两个数量性状的多效性的双基因座模型。
DOI: 10.1093/genetics/112.3.717
发表时间: 1986
期刊: Genetics
影响因子: 3.3
作者:
Gimelfarb,A
通讯作者: Gimelfarb,A
空间异质环境中遗传变异的演化:基因型-环境相互作用的影响。
DOI: 10.1017/s001667230002694x
发表时间: 1987
期刊: Genetical research
影响因子: --
作者:
Via,S;Lande,R
通讯作者: Lande,R
优化选择、突变和漂移下多基因性状的遗传变异。
DOI: --
发表时间: 1972
期刊: Genetical research
影响因子: --
作者:
M. Bulmer
通讯作者: M. Bulmer