Does the arthropod microbiota impact the establishment of vector-borne diseases in mammalian hosts?
Does the arthropod microbiota impact the establishment of vector-borne diseases in mammalian hosts?
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DOI：
10.1371/journal.ppat.1004646
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发表时间：
2015-04
期刊：
影响因子：
6.7
通讯作者：
Wasmuth JD
中科院分区：
文献类型：
--
作者：
Finney CA;Kamhawi S;Wasmuth JD
微生物群对宿主免疫状态的影响是一个密集研究和宣传的来源。相比之下，节肢动物微生物群对媒介传播的传染病的影响很少受到关注。更好地了解与哺乳动物宿主免疫反应有关的病媒微生物群至关重要，因为它可以在一个疫苗很少、有效治疗很少的研究领域制定影响传播和改进疫苗设计的战略。最近关于微生物群如何减少节肢动物中病原体的发展，从而改变媒介对媒介传播疾病（VBDs）的许可性的证明引起了人们新的兴趣。然而，关于节肢动物衍生微生物群与哺乳动物宿主之间相互作用的假设尚未得到解决。DNA测序技术的进步、产量的提高和成本的下降，意味着这些研究现在对许多微生物学家和昆虫学家来说是可行的。在这里，我们提炼现有的知识，提出关键问题和实验设计，以阐明这一新兴的研究课题。
The impact of the microbiota on the immune status of its host is a source of intense research and publicity. In comparison, the effect of arthropod microbiota on vector-borne infectious diseases has received little attention. A better understanding of the vector microbiota in relation to mammalian host immune responses is vital, as it can lead to strategies that affect transmission and improve vaccine design in a field of research where few vaccines exist and effective treatment is rare. Recent demonstrations of how microbiota decrease pathogen development in arthropods, and thus alter vector permissiveness to vector-borne diseases (VBDs), have led to renewed interest. However, hypotheses on the interactions between the arthropod-derived microbiota and the mammalian hosts have yet to be addressed. Advances in DNA sequencing technology, increased yield and falling costs, mean that these studies are now feasible for many microbiologists and entomologists. Here, we distill current knowledge and put forward key questions and experimental designs to shed light on this burgeoning research topic.
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