BmK-YA, an enkephalin-like peptide in scorpion venom.
BmK-YA, an enkephalin-like peptide in scorpion venom.
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DOI：
10.1371/journal.pone.0040417
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Civelli O
中科院分区：
文献类型：
--
作者：
Zhang Y;Xu J;Wang Z;Zhang X;Liang X;Civelli O
通过筛选亚洲蝎子Buthus martensii Karsch （BmK）毒液提取物激活阿片受体的能力，我们鉴定了BmK- ya，一种含有脑啡肽样序列的修饰肽。BmK-YA由一个前体编码，该前体显示一个信号序列，包含BmK-YA序列的四个拷贝和His4-BmK-YA的四个拷贝，它们的两侧都有单个氨基酸残基。BmK-YA和His4-BmK-YA经过修饰，符合生物活性肽的特性。BmK-YA可选择性激活哺乳动物阿片受体δ亚型，而His4-BmK-YA对阿片受体无活性。BmK-YA的发现表明，蝎子毒液可能是一种靶向G蛋白偶联受体（gpcr）的生物活性分子的新来源，并为阿片前体的进化提供了新的见解。
By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor that displays a signal sequence and contains four copies of BmK-YA sequences and four of His4-BmK-YA, all flanked by single amino acid residues. BmK-YA and His4-BmK-YA are amidated and thus fulfill the characteristics expected of bioactive peptides. BmK-YA can activate mammalian opioid receptors with selectivity for the δ subtype while His4-BmK-YA is inactive at opioid receptors. The discovery of BmK-YA suggests that scorpion venom may represent a novel source of bioactive molecules targeting G protein-coupled receptors (GPCRs) and reveal additional insights on the evolution of the opioid precursors.
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影响因子：
2.8
作者：
Koivula, Katja;Rondinelli, Sergio;Nasman, Johnny
通讯作者：
Nasman, Johnny
影响因子：
1.6
作者：
Liu, YF;Ma, RL;Wu, CF
通讯作者：
Wu, CF
DOI：
10.1196/annals.1327.003
发表时间：
2005-01-01
期刊：
TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY
影响因子：
--
作者：
Khalap, A;Bagrosky, B;Dores, RM
通讯作者：
Dores, RM
影响因子：
7.3
作者：
Quinton, L.;Girard, E.;Gilles, N.
通讯作者：
Gilles, N.
DOI：
10.1073/pnas.80.16.5144
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
EIPPER, BA;MAINS, RE;GLEMBOTSKI, CC
通讯作者：
GLEMBOTSKI, CC