Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.
Noninvasive LV pressure estimation using subharmonic emissions from microbubbles.
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DOI：
10.1016/j.jcmg.2011.08.017
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Forsberg F
中科院分区：
文献类型：
--
作者：
Dave JK;Halldorsdottir VG;Eisenbrey JR;Raichlen JS;Liu JB;McDonald ME;Dickie K;Wang S;Leung C;Forsberg F
本研究的目的是开发和研究一种新的无创方法来量化左心室（LV）压力，使用微泡的次谐波发射。在脉冲反转灰度模式下使用带有PA 4 -2相控阵换能器的Sonix RP超声扫描仪。在Sonazoid输注期间，使用脉冲波多普勒从4只犬的主动脉和/或LV获得5秒（n=3）的未处理射频数据。使用Millar压力计同时获得压力测量值。提取并处理分谐波数据（dB）。来自主动脉的校准因子（mmHg/dB）用于估计LV压力。当使用来自相应犬的主动脉校准因子估计这些压力时，误差范围为0.19至2.50 mmHg;但当使用平均主动脉校准因子时，误差明显更高（0.64-8.98 mmHg）。总之，超声造影剂的次谐波发射具有无创监测LV压力的潜力。
The purpose of this study was to develop and investigate a new noninvasive approach to quantify left ventricular (LV) pressures using subharmonic emissions from microbubbles. A Sonix RP ultrasound scanner with PA4-2 phased array transducer was used in pulse inversion grayscale mode. Unprocessed radiofrequency data were obtained for 5 seconds (n=3) with pulsed wave Doppler from the aorta and/or LV of 4 canines during Sonazoid infusion. Simultaneous pressure measurements were obtained using Millar manometer. Subharmonic data (in dB) were extracted and processed. The resulting calibration factor (mmHg/dB), from the aorta, was used to estimate LV pressures. Errors ranged from 0.19 to 2.50 mmHg when estimating these pressures using the aortic calibration factor from the respective canines; but were considerably higher (0.64-8.98 mmHg) when a mean aortic calibration factor was used. In conclusion, subharmonic emissions from ultrasound contrast agents have the potential to noninvasively monitor LV pressures.
影响因子：
2.3
作者：
Halldorsdottir VG;Dave JK;Leodore LM;Eisenbrey JR;Park S;Hall AL;Thomenius K;Forsberg F
通讯作者：
Forsberg F
影响因子：
2.9
作者：
Shi, WT;Forsberg, F;Goldberg, BB
通讯作者：
Goldberg, BB
影响因子：
37.8
作者：
Chatterjee, Kanu
通讯作者：
Chatterjee, Kanu