Subharmonic contrast microbubble signals for noninvasive pressure estimation under static and dynamic flow conditions.
Subharmonic contrast microbubble signals for noninvasive pressure estimation under static and dynamic flow conditions.
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DOI：
10.1177/016173461103300301
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发表时间：
2011-07
影响因子：
2.3
通讯作者：
Forsberg F
中科院分区：
文献类型：
--
作者：
Halldorsdottir VG;Dave JK;Leodore LM;Eisenbrey JR;Park S;Hall AL;Thomenius K;Forsberg F
我们的小组已经提出了亚谐波辅助压力估计（SHAPE）的概念，利用基于微泡的超声造影剂信号的无创估计的静水血压。基于两个以60°角共焦组装的单元件换能器构建了体外SHAPE实验系统。在静态静水压力从0到186 mmHg，声压从0.35-0.60 MPa峰到峰和频率为2.5-6.6 MHz时，在体外测量五种不同超声造影剂的第一，第二和次谐波振幅的变化。使用线性回归分析确定用于SHAPE的最敏感试剂和最佳参数，并在Logiq 9扫描仪（GE Healthcare，密尔沃基，WI）上实施。然后在动态流动条件下测试SHAPE的这种实现，并与压力导管测量进行比较。在研究的压力范围内，所有造影剂的一次和二次谐波振幅均降低约2 dB。在相同的压力范围内，次谐波振幅降低9-14 dB，并实现了与静水压力变化的良好线性回归（r2 ≥ 0.98，p < 0.001）。使用Sonazoid（GE Healthcare，奥斯陆，挪威）在2.5 MHz的发射频率和0.35 MPa的声压下实现了最佳灵敏度。修改Logiq 9扫描仪，在频率范围为1.5-4.5 MHz，声压范围为0 - 3.34 MPa的凸形换能器上实施SHAPE，结果与压力导管匹配（r2 = 0.87）。总之，次谐波对比信号是流体静压的良好指示器。在所测试的五种超声造影剂中，Sonazoid对次谐波压力估计最敏感。实时SHAPE已在商业扫描仪上实现，并提供了非侵入性获得心脏和其他部位压力的可能性。
Our group has proposed the concept of subharmonic aided pressure estimation (SHAPE) utilizing microbubble-based ultrasound contrast agent signals for the noninvasive estimation of hydrostatic blood pressures. An experimental system for in vitro SHAPE was constructed based on two single-element transducers assembled confocally at a 60° angle to each other. Changes in the first, second, and subharmonic amplitudes of five different ultrasound contrast agents were measured in vitro at static hydrostatic pressures from 0 to 186 mmHg, acoustic pressures from 0.35–0.60 MPa peak to peak and frequencies of 2.5–6.6 MHz. The most sensitive agent and optimal parameters for SHAPE were determined using linear regression analysis and implemented on a Logiq 9 scanner (GE Healthcare, Milwaukee, WI). This implementation of SHAPE was then tested under dynamic flow conditions and compared to pressure catheter measurements. Over the pressure range studied the first and second harmonic amplitudes reduced approximately 2 dB for all contrast agents. Over the same pressure range, the subharmonic amplitudes decreased by 9–14 dB and excellent linear regressions were achieved with the hydrostatic pressure variations (r2 ≥ 0.98, p < 0.001). The optimal sensitivity was achieved at a transmit frequency of 2.5 MHz and an acoustic pressure of 0.35 MPa using Sonazoid (GE Healthcare, Oslo, Norway). A Logiq 9 scanner was modified to implement SHAPE on a convex transducer with a frequency range from 1.5–4.5 MHz, acoustic pressures from 0 to 3.34 MPa, and results matched the pressure catheter (r2 = 0.87). In conclusion, subharmonic contrast signals are a good indicator of hydrostatic pressure. Out of the five ultrasound contrast agents tested Sonazoid was the most sensitive for subharmonic pressure estimation. Real-time SHAPE has been implemented on a commercial scanner and offers the possibility of allowing pressures in the heart and elsewhere to be obtained noninvasively.
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影响因子：
2.9
作者：
Shi, WT;Forsberg, F;Goldberg, BB
通讯作者：
Goldberg, BB
影响因子：
4.2
作者：
Forsberg, F;Shi, WT;Goldberg, BB
通讯作者：
Goldberg, BB
DOI：
10.1109/tuffc.2005.1397351
发表时间：
2005-01-01
影响因子：
3.6
作者：
Goertz, DE;Cherin, E;Foster, FS
通讯作者：
Foster, FS
影响因子：
2.9
作者：
Reddy, AK;Taffet, GE;Hartley, CJ
通讯作者：
Hartley, CJ
影响因子：
2.9
作者：
Needles, A.;Goertz, D. E.;Foster, F. S.
通讯作者：
Foster, F. S.