APOE ε4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation.
APOE ε4 status in healthy older African Americans is associated with deficits in pattern separation and hippocampal hyperactivation.
复制标题
健康老年美国人的APOEε4状态与模式分离和海马过度激活的缺陷有关。
DOI：
10.1016/j.neurobiolaging.2018.05.023
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发表时间：
2018-09
影响因子：
4.2
通讯作者：
Gluck MA
中科院分区：
文献类型：
--
作者：
Sinha N;Berg CN;Tustison NJ;Shaw A;Hill D;Yassa MA;Gluck MA
非裔美国人携带 APOE ε4 等位基因的可能性是欧洲裔美国人的 1.4 倍，APOE ε4 是阿尔茨海默病 (AD) 的危险因素。然而，人们对老年非裔美国人认知功能的神经相关性以及它们与 AD 遗传风险的关系知之甚少。特别是，过去没有针对非裔美国人的研究检验过 APOE ε4 状态对模式分离——助记辨别能力及其在海马体中相应神经计算的影响。先前使用助记辨别范式的工作已将 DG/CA3 海马亚区域的激活增加定位为与辨别缺陷相关。在一项针对 30 名 60 岁及以上健康非洲裔美国人的病例对照高分辨率功能磁共振成像研究中，我们观察到 APOE ε4 相关的助记辨别损伤，与 DG/CA3 和 CA1 区域功能失调的过度激活一致，尽管没有证据表明携带者和非携带者之间的海马结构存在差异。我们的研究结果进一步证明，模式分离缺陷可能是 AD 相关神经元功能障碍的早期标志。
African Americans are 1.4 times more likely than European Americans to carry the APOE ε4 allele, a risk factor for Alzheimer’s disease (AD). However, little is known about the neural correlates of cognitive function in older African Americans and how they relate to genetic risk for AD. In particular, no past study on African Americans has examined the effect of APOE ε4 status on pattern separation—mnemonic discrimination performance and its corresponding neural computations in the hippocampus. Previous work using the mnemonic discrimination paradigm has localized increased activation in the DG/CA3 hippocampal sub-regions as being correlated with discrimination deficits. In a case-control high-resolution fMRI study of 30 healthy African Americans, ages 60 and older, we observed APOE ε4 related impairments in mnemonic discrimination, coincident with dysfunctional hyperactivation in the DG/CA3 and CA1 regions, despite no evidence of structural differences in the hippocampus between carriers and non-carriers. Our results add to the growing body of evidence that deficits in pattern separation may be an early marker for AD related neuronal dysfunction.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1016/j.jalz.2009.07.003
发表时间：
2010-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
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影响因子：
11
作者：
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通讯作者：
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影响因子：
4.2
作者：
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影响因子：
16.2
作者：
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通讯作者：
Gallagher M