Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment.
Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment.
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DOI：
10.1016/j.neuron.2012.03.023
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发表时间：
2012-05-10
期刊：
影响因子：
16.2
通讯作者：
Gallagher M
中科院分区：
文献类型：
--
作者：
Bakker A;Krauss GL;Albert MS;Speck CL;Jones LR;Stark CE;Yassa MA;Bassett SS;Shelton AL;Gallagher M
在阿尔茨海默病的风险状况下，包括遗忘型轻度认知障碍（aMCI），会观察到海马体激活增强。相关动物模型的研究表明，选择性海马回路的过度活动会导致认知障碍。在此我们测试了降低遗忘型轻度认知障碍中海马体激活的效果。在安慰剂治疗下，与健康对照组相比，遗忘型轻度认知障碍患者齿状回/CA3的海马体激活增强。通过使用低剂量的抗癫痫药物左乙拉西坦，遗忘型轻度认知障碍患者的海马体激活降低到与对照组无差异的水平。与安慰剂下遗忘型轻度认知障碍的记忆表现相比，药物治疗下扫描任务的表现显著提高。与海马体激活增强可能具有有益功能的观点相反，这些结果支持遗忘型轻度认知障碍中海马体激活增加是一种功能失调的状况，并且针对海马体过度活动具有治疗潜力这一观点。
Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal models have indicated that over-activity in selective hippocampal circuits contributes to cognitive impairment. Here we tested the effect of reducing hippocampal activation in aMCI. Under placebo treatment, hippocampal activation in the dentate gyrus/CA3 was elevated in aMCI patients compared to a healthy control group. By using a low dose of the antiepileptic levetiracetam hippocampal activation in aMCI was reduced to a level that did not differ from the control group. Compared to aMCI memory performance under placebo, performance in the scanning task was significantly improved under drug treatment. Contrary to the view that greater hippocampal activation might serve a beneficial function, these results support the view that increased hippocampal activation in aMCI is a dysfunctional condition and that targeting excess hippocampal activity has therapeutic potential.
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影响因子：
11
作者：
Miller, S. L.;Fenstermacher, E.;Dickerson, B. C.
通讯作者：
Dickerson, B. C.
DOI：
10.1016/j.jalz.2009.07.003
发表时间：
2010-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Dennis NA;Browndyke JN;Stokes J;Need A;Burke JR;Welsh-Bohmer KA;Cabeza R
通讯作者：
Cabeza R
影响因子：
15.9
作者：
Ewers M;Sperling RA;Klunk WE;Weiner MW;Hampel H
通讯作者：
Hampel H
影响因子：
11.2
作者：
Quiroz, Yakeel T.;Budson, Andrew E.;Celone, Kim;Ruiz, Adriana;Newmark, Rardall;Castrillon, Gabriel;Lopera, Francisco;Stern, Chantal E.
通讯作者：
Stern, Chantal E.
影响因子：
16.2
作者：
Palop, Jorge J.;Chin, Jeannie;Mucke, Lennart
通讯作者：
Mucke, Lennart