A treatment trial of acupuncture in IBS patients.
A treatment trial of acupuncture in IBS patients.
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DOI：
10.1038/ajg.2009.156
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发表时间：
2009-06
影响因子：
9.8
通讯作者：
Kaptchuk, Ted J.
中科院分区：
文献类型：
--
作者：
Lembo, Anthony J.;Conboy, Lisa;Kelley, John M.;Schnyer, Rosa S.;McManus, Claire A.;Quilty, Mary T.;Kerr, Catherine E.;Drossman, Doug;Jacobson, Eric E.;Davis, Roger B.;Kaptchuk, Ted J.
比较真、假针刺对IBS症状的缓解作用。共有230名成年IBS患者(75%是女性，平均年龄38.4岁)被随机分配到真针灸或假针灸(6种治疗)3周，在与假针灸进行3周的磨合后，患者与医生进行“增强的”或“有限的”互动。这项研究的第三组包括等待名单控制组。主要结果是IBS全球改善量表(IBS-GIS)(范围1-7)；次要结果包括IBS症状严重程度量表(IBS-SSS)、适当缓解(IBS-AR)和IBS生活质量(IBS-QOL)。尽管针刺和假针刺对肠易激综合征-地理信息系统的改善没有统计学意义(41%比32%，p=0.001)，但两组都比等待名单对照组(37%比4%，p=0.001)有显著改善。同样，在其他三个结果上，没有统计学意义的微小差异有利于针灸：IBS-AR(59%比57%，p=0.83)，IBS-SSS(31%比21%，p=0.18)和IBS-QOL(17%比13%，p=0.56)。在磨合期淘汰应答者并没有实质性地改变结果。针刺组的副作用一般较轻，只是略大一些。这项研究没有发现证据支持针灸在治疗IBS方面优于假针灸。
To compare the effects of true and sham acupuncture in relieving symptoms of IBS. A total of 230 adult IBS patients (75% females, average age 38.4 yrs) were randomly assigned to 3 weeks of true or sham acupuncture (6 treatments) following a 3 week ‘run-in’ with sham acupuncture in an ‘augmented’ or ‘limited’ patient-practitioner interaction. A third arm of the study included a waitlist control group. The primary outcome was the IBS Global Improvement Scale (IBS-GIS) (range 1–7); secondary outcomes included IBS Symptom Severity Scale (IBS-SSS), Adequate Relief (IBS-AR) and IBS-Quality of life (IBS-QOL). Though there was no statistically significant difference between acupuncture and sham acupuncture on the IBS-GIS (41% vs. 32%, p=0.25), both groups improved significantly compared to the wait list control group (37% vs. 4%, p=0.001). Similarly, small differences that were not statistically significant favored acupuncture on the other three outcomes: IBS-AR (59% vs 57%, p=0.83), IBS-SSS (31% vs 21%, p=0.18) and IBS-QOL (17% vs 13%, p=0.56). Eliminating responders during the run-in period did not substantively change the results. Side effects were generally mild and only slightly greater in the acupuncture group. This study did not find evidence to support the superiority of acupuncture compared to sham acupuncture in the treatment of IBS.
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