Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression.
Nicotine and networks: Potential for enhancement of mood and cognition in late-life depression.
复制标题
DOI：
10.1016/j.neubiorev.2017.08.018
复制
发表时间：
2018-01
影响因子：
8.2
通讯作者：
Taylor WD
中科院分区：
文献类型：
--
作者：
Gandelman JA;Newhouse P;Taylor WD
老年抑郁症的特点是情绪低落和认知能力差，这些症状通常对目前的抗抑郁药物没有完全反应。烟碱乙酰胆碱受体（nAChR）激动剂如尼古丁可能作为一种新的治疗方法。临床前和初步临床研究表明，nAChR激动剂可以改善动物模型的抑郁行为，改善抑郁个体的情绪。大量文献也支持nAChR激动剂有益于认知表现，特别是在老年人中。这些潜在的益处可能是由nAChR刺激对神经网络功能和连通性的影响介导的。功能性神经影像学研究了nAChR激动剂对默认模式网络、中央-执行网络和显著性网络的详细影响，这些网络可能会反对或逆转抑郁症中所见的网络变化。我们认为，鉴于现有的文献和老年抑郁症的临床表现，尼古丁或其他nAChR激动剂可能在这一人群中具有独特的治疗效果，并且在老年抑郁症中检测尼古丁对情绪、认知和网络动态的影响的临床试验是合理的。
Late-life depression is characterized by both lower mood and poor cognitive performance, symptoms that often do not fully respond to current antidepressant medications. Nicotinic acetylcholine receptor (nAChR) agonists such as nicotine may serve as a novel therapeutic approach for this population. Both preclinical and preliminary clinical studies suggest that nAChR agonists can improve depressive behavior in animal models and improve mood in depressed individuals. Substantial literature also supports that nAChR agonists benefit cognitive performance, particularly in older populations. These potential benefits may be mediated by the effects of nAChR stimulation on neural network function and connectivity. Functional neuroimaging studies detail effects of nAChR agonists on the default mode network, central-executive network, and salience network that may oppose or reverse network changes seen in depression. We propose that, given the existent literature and the clinical presentation of late-life depression, nicotine or other nAChR agonists may have unique therapeutic benefits in this population and that clinical trials examining nicotine effects on mood, cognition, and network dynamics in late-life depression are justified.
登录
查看更多内容
影响因子：
--
作者：
Beekman, ATF;Geerlings, SW;van Tilburg, W
通讯作者：
van Tilburg, W
影响因子：
2.7
作者：
Andreasen, Jesper T.;Redrobe, John P.
通讯作者：
Redrobe, John P.
哺乳动物烟碱乙酰胆碱受体：从结构到功能。
影响因子：
33.6
作者：
Albuquerque EX;Pereira EF;Alkondon M;Rogers SW
通讯作者：
Rogers SW
影响因子：
5.2
作者：
Andrews-Hanna JR;Smallwood J;Spreng RN
通讯作者：
Spreng RN
影响因子：
10.6
作者：
Avery, Jason A.;Drevets, Wayne C.;Moseman, Scott E.;Bodurka, Jerzy;Barcalow, Joel C.;Simmons, W. Kyle
通讯作者：
Simmons, W. Kyle