Ethnic differences in the accumulation of fat and lean mass in late gestation.
Ethnic differences in the accumulation of fat and lean mass in late gestation.
复制标题
DOI：
10.1002/ajhb.22285
复制
发表时间：
2012-09
影响因子：
2.9
通讯作者：
Romero, Roberto
中科院分区：
文献类型：
--
作者：
Lampl, Michelle;Lee, Wesley;Koo, Winston;Frongillo, Edward A.;Barker, David J. P.;Romero, Roberto
正常范围内的较低出生体重预示着成人慢性疾病，但不同种族群体的相同出生体重可能反映了不同的组织发育模式。研究了非西班牙裔高加索人和非洲裔美国人的新生儿身体组成，利用妊娠期的变化来了解妊娠晚期的生长情况。空气置换体积描记法评估了220名非西班牙裔白人和93名非西班牙裔非洲裔美国新生儿的脂肪和瘦体重。使用线性回归对两个种族组进行比较。妊娠36周时，白人新生儿的平均瘦体重为2，515 g，而非裔美国新生儿的平均瘦体重为2，319 g（差异，P = 0.02）。脂肪量的相应数字分别为231和278 g（差异，P = 0.24）。在41周时，白人的瘦体重增加了319 g（P < 0.001），但脂肪量也增加了123 g（P = 0.001）。瘦体重与孕周的斜率相似，但白人（41.0 g/周）的脂肪量斜率是非裔美国新生儿（7.0 g/周）的5.8倍（P = 0.009）。到妊娠36周时，非裔美国人胎儿的脂肪量与白人胎儿相似，瘦体重较少。此后，随着出生时胎龄的增加，非裔美国人胎儿的瘦体重变化与白人胎儿相似，但脂肪积累更慢。我们推测，不同种族的胎儿生长策略，包括身体成分可能有助于种族的健康差异在以后的生活。
Lower birth weight within the normal range predicts adult chronic diseases, but the same birth weight in different ethnic groups may reflect different patterns of tissue development. Neonatal body composition was investigated among non-Hispanic Caucasians and African Americans, taking advantage of variability in gestational duration to understand growth during late gestation. Air displacement plethysmography assessed fat and lean body mass among 220 non-Hispanic Caucasian and 93 non-Hispanic African American neonates. The two ethnic groups were compared using linear regression. At 36 weeks gestation, the average lean mass of Caucasian neonates was 2,515 g vs. that of 2,319 g of African American neonates (difference, P = 0.02). The corresponding figures for fat mass were 231 and 278 g, respectively (difference, P = 0.24). At 41 weeks, the Caucasians were 319 g heavier in lean body mass (P < 0.001) but were also 123 g heavier in fat mass (P = 0.001). The slopes for lean mass vs. gestational week were similar, but the slope of fat mass was 5.8 times greater (P = 0.009) for Caucasian (41.0 g/week) than for African American neonates (7.0 g/week). By 36 weeks of gestation, the African American fetus developed similar fat mass and less lean mass compared with the Caucasian fetus. Thereafter, changes in lean mass among the African American fetus with increasing gestational age at birth were similar to the Caucasian fetus, but fat accumulated more slowly. We hypothesize that different ethnic fetal growth strategies involving body composition may contribute to ethnic health disparities in later life.
登录
查看更多内容
影响因子：
4.4
作者：
Bang, Oh Young;Saver, Jeffrey L.;Liebeskind, David S.;Pineda, Sandra;Yun, Susan W.;Ovbiagele, Bruce
通讯作者：
Ovbiagele, Bruce
DOI：
10.1016/s0002-9378(03)00828-7
发表时间：
2003-12-01
影响因子：
9.8
作者：
Catalano, PM;Thomas, A;Amini, SB
通讯作者：
Amini, SB
影响因子：
8
作者：
Alexander, GR;Kogan, M;Mor, J
通讯作者：
Mor, J
影响因子：
2.9
作者：
Jasienska, Grazyna
通讯作者：
Jasienska, Grazyna
影响因子：
3.8
作者：
Casazza, K.;Dulin-Keita, A.;Fernandez, J. R.
通讯作者：
Fernandez, J. R.