Roles of CXCL5 on migration and invasion of liver cancer cells.
Roles of CXCL5 on migration and invasion of liver cancer cells.
复制标题
CXCL5对肝癌细胞迁移和侵袭的作用
DOI：
10.1186/1479-5876-12-193
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发表时间：
2014-07-10
影响因子：
7.4
通讯作者：
Xia J
中科院分区：
文献类型：
--
作者：
Xu X;Huang P;Yang B;Wang X;Xia J
炎症因子在肝癌的发展中起着至关重要的作用，尽管确切的因素和相关机制尚不清楚。本研究旨在筛选与肝癌转移相关的炎症因子，探讨肝癌细胞募集的潜在机制。我们通过芯片和RT-PCR筛选和验证炎症因子。采用小干扰RNA （siRNA）和重组蛋白评价CXCL5对肝癌细胞（lcc）运动的影响。我们的筛选芯片显示CXCL5在具有高转移潜力的lcc中过表达。CXCL5可能通过自分泌和旁分泌机制增加lcc的迁移和侵袭。CXCL5-CXCR2和ERK1/2通路可能在lcc迁移调控中发挥关键作用。我们的数据表明，lcc本身可能作为CXCL5的产生者和受体，负责肝癌的迁移和侵袭。
Inflammatory factors play a vital role in the progression of liver cancer, although exact factors and related mechanisms still remain unclear. The present study aimed at screening inflammatory factors related to liver cancer metastasis and investigating the potential mechanism by which cancer cells are recruited. We screened and validated inflammatory factors by microarray and RT-PCR. Small interfering RNA (siRNA) and recombinant protein were used to assess CXCL5 effects on the movement of liver cancer cells (LCCs). Our screening microarray demonstrated over-expression of CXCL5 in LCCs with high metastatic potentials. CXCL5 increased LCCs migration and invasion, probably through autocrine and paracrine mechanisms. CXCL5-CXCR2 and ERK1/2 pathways could play critical roles in the regulation of LCCs migration. Our data indicates that LCCs per se may act as the producer and receptor of CXCL5 responsible for liver cancer migration and invasion.
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影响因子：
8.8
作者：
Tian J;Tang ZY;Ye SL;Liu YK;Lin ZY;Chen J;Xue Q
通讯作者：
Xue Q
DOI：
10.1007/s00432-007-0225-x
发表时间：
2007-11-01
影响因子：
3.6
作者：
Park, Jeong Youp;Park, Kyung Hwa;Song, Si Young
通讯作者：
Song, Si Young
影响因子：
3.8
作者：
Pappa, C. A.;Tsirakis, G.;Alexandrakis, M. G.
通讯作者：
Alexandrakis, M. G.
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影响因子：
15.3
作者：
Walz, A;Burgener, R;Car, B;Baggiolini, M;Kunkel, S L;Strieter, R M
通讯作者：
Strieter, R M
影响因子：
5.6
作者：
Kuo, Po-Lin;Chen, Yen-Hsu;Hsu, Ya-Ling
通讯作者：
Hsu, Ya-Ling