Sleep quality and outcome of exposure therapy in adults with social anxiety disorder.
Sleep quality and outcome of exposure therapy in adults with social anxiety disorder.
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DOI：
10.1002/da.23167
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发表时间：
2021-11
影响因子：
7.4
通讯作者：
Smits JAJ
中科院分区：
文献类型：
--
作者：
Dutcher CD;Dowd SM;Zalta AK;Taylor DJ;Rosenfield D;Perrone A;Otto MW;Pollack MH;Hofmann SG;Smits JAJ
睡眠不佳在社交焦虑障碍（SAD）患者中很普遍，可能会对暴露治疗的结果产生负面影响。睡眠不好可能会损害记忆和学习，从而损害被认为在暴露疗法中发生的恐惧消退学习。我们研究了睡眠不佳作为SAD暴露治疗结果的预测因子，以及D-环丝氨酸（DCS）在这种关系中的调节作用。参与者是152名初步诊断为SAD的人。作为评估DCS增强暴露疗法效果的随机临床试验的一部分，他们完成了睡眠质量的自我报告基线测量，以及评估睡眠持续时间（总睡眠时间[TST]）和治疗前后夜晚睡眠质量的自我报告睡眠日记。在控制了抑郁和社交焦虑的基线症状后，在治疗结束和随访时，患者的基线睡眠质量随着时间的推移与缓慢的改善和更差的症状结局显著相关。治疗前一天晚上的TST越大，在控制了前一个疗程的症状后，下一个疗程的SAD症状越低。之前或之后的夜间睡眠质量与下一次会议的症状之间没有关系。DCS没有主持任何关联。我们重复并扩展了研究结果，表明睡眠质量差与SAD暴露治疗结果较差相关。在治疗开始前评估睡眠困难并将睡眠干预纳入治疗可能会增强SAD的暴露治疗结局。
Poor sleep is prevalent among individuals with social anxiety disorder (SAD) and may negatively affect exposure therapy outcomes. Poor sleep may impair memory and learning, and thus compromise fear extinction learning thought to take place in exposure therapy. We examined poor sleep as a predictor of exposure therapy outcomes for SAD and the moderating role of D-cycloserine (DCS) on this relationship. Participants were 152 individuals with a primary diagnosis of SAD. As part of a randomized clinical trial evaluating the efficacy of DCS for enhancing the effects of exposure therapy, they completed self-report baseline measure of sleep quality, and self-report sleep diaries assessing sleep duration (total sleep time [TST]) and sleep quality the nights prior to and after treatment sessions. Poorer baseline sleep quality was significantly associated with slower improvement over time and worse symptom outcomes at the end of treatment and follow-up after controlling for baseline symptoms of depression and social anxiety. Greater TST the night prior to treatment predicted lower SAD symptoms at the next session, after controlling for symptoms at the previous session. There was no relation between prior or subsequent night sleep quality on symptoms at the next session. No associations were moderated by DCS. We replicated and extended findings indicating that poor sleep quality is associated with poorer exposure therapy outcomes for SAD. Assessing for sleep difficulties prior to treatment initiation and incorporating sleep interventions into treatment may enhance exposure therapy outcomes for SAD.
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从分子到全脑网络的睡眠，可塑性和记忆力。
影响因子：
9.2
作者：
Abel, Ted;Havekes, Robbert;Saletin, Jared M.;Walker, Matthew P.
通讯作者：
Walker, Matthew P.
影响因子：
--
作者：
Hofmann, SG;Meuret, AE;Otto, MW
通讯作者：
Otto, MW
影响因子：
6.9
作者：
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通讯作者：
Rasch, B.
影响因子：
12.6
作者：
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通讯作者：
Smith, Rita
DOI：
10.1038/nrn.2017.55
发表时间：
2017-07
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Krause AJ;Simon EB;Mander BA;Greer SM;Saletin JM;Goldstein-Piekarski AN;Walker MP
通讯作者：
Walker MP