Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions.
Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions.
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DOI：
10.1016/j.neuron.2021.11.029
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发表时间：
2022-03-02
期刊：
影响因子：
16.2
通讯作者：
Han S
中科院分区：
文献类型：
--
作者：
Liu S;Ye M;Pao GM;Song SM;Jhang J;Jiang H;Kim JH;Kang SJ;Kim DI;Han S
呼吸可能会受到疼痛或内部情绪状态的严重影响，但这种紧密协调背后的神经回路尚不清楚。在这里，我们报道了外侧臂旁核（PBL）中表达 Oprm1（μ-阿片受体）的神经元对于协调小鼠呼吸与情感疼痛至关重要。个体 PBLOprm1 神经元活动与呼吸节律同步并对有害刺激做出反应。操纵 PBLOprm1 活性会直接改变呼吸频率、情感疼痛感知和焦虑。此外，PBLOprm1 神经元以“核-壳”结构构成两个不同的亚群，分别投射到前脑和后脑。通过对中央杏仁核和前 Bötzinger 复合体的非重叠投射，这两个亚群有差异地调节呼吸、情感疼痛和负面情绪。此外，这些子集通过相互的谷氨酸能投射形成循环兴奋网络。总之，我们的数据将不同的臂旁阿片能回路定义为一种共同的神经基质，可以协调呼吸与各种感觉和行为，例如疼痛和情绪处理。呼吸可能受到疼痛和焦虑的影响，但这种联系背后的神经基础尚不清楚。刘等人。报道称，表达μ阿片受体的外侧臂旁核神经元通过不同的输出电路和局部循环网络协调小鼠的呼吸与情感疼痛和负面情绪。
Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the lateral parabrachial nucleus (PBL) are crucial for coordinating breathing with affective pain in mice. Individual PBLOprm1 neuronal activity synchronizes with breathing rhythm and responds to noxious stimuli. Manipulating PBLOprm1 activity directly changes breathing rate, affective pain perception, and anxiety. Furthermore, PBLOprm1 neurons constitute two distinct subpopulations in a “core-shell” configuration that divergently projects to the forebrain and hindbrain. Through non-overlapping projections to the central amygdala and pre-Bötzinger complex, these two subpopulations differentially regulate breathing, affective pain, and negative emotions. Moreover, these subsets form recurrent excitatory networks through reciprocal glutamatergic projections. Together, our data define the divergent parabrachial opioidergic circuits as a common neural substrate that coordinates breathing with various sensations and behaviors such as pain and emotional processing. Breathing can be influenced by pain and anxiety, but the neural substrate underlying this connection is unknown. Liu et al. report that neurons in the lateral parabrachial nucleus expressing the μ-opioid receptor coordinate breathing with affective pain and negative emotions through divergent output circuits and local recurrent networks in mice.
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