Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography.
Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography.
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DOI：
10.1038/s41598-017-08968-x
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发表时间：
2017-08-17
影响因子：
4.6
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Jing JC;Chen JJ;Chou L;Wong BJF;Chen Z
纤毛运动在上气道的整体呼吸健康中起着关键作用。这些纤毛以固有频率和同步模式跳动，以连续地将被困在粘液层中的外来颗粒输送出上气道。纤毛运动的中断可导致严重的呼吸系统疾病和呼吸功能受损。目前，纤毛的研究需要昂贵的高速相机和高功率显微镜，这是不适合在体内成像和诊断。基于多普勒的光学相干断层扫描具有可视化纤毛在其跳动周期期间的微观运动的潜力。我们展示了一种高速多普勒光学相干断层扫描系统的发展，不仅可以快速确定纤毛拍频，但也同时可视化的颞纤毛跳动模式，在纤毛功能中起着关键作用。
Ciliary motion plays a critical role in the overall respiratory health of the upper airway. These cilia beat at a native frequency and in a synchronized pattern to continuously transport foreign particulate trapped in a layer of mucous out of the upper airway. Disruption of ciliary motion can lead to severe respiratory diseases and compromised respiratory function. Currently, the study of cilia requires expensive high speed cameras and high powered microscopes which is unsuitable for in vivo imaging and diagnosis. Doppler based optical coherence tomography has the potential to visualize the microscopic motion of cilia during their beating cycle. We demonstrate the development of a high-speed Doppler optical coherence tomography system that not only can rapidly determine the cilia beat frequency, but also simultaneously visualize the temporal cilia beating pattern which plays critical roles in cilia function.
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影响因子：
2.9
作者：
Kim, Woojae;Han, Tae Hwa;Park, Rae Woong
通讯作者：
Park, Rae Woong
影响因子：
2.1
作者：
GREEN, A;SMALLMAN, LA;DRAKELEE, AB
通讯作者：
DRAKELEE, AB
DOI：
10.1098/rspb.1930.0075
发表时间：
1930-12-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER
影响因子：
--
作者：
Gray, J
通讯作者：
Gray, J
影响因子：
48
作者：
Barretto, Robert P. J.;Messerschmidt, Bernhard;Schnitzer, Mark J.
通讯作者：
Schnitzer, Mark J.
影响因子：
64.8
作者：
DALHAMN, T;RYLANDER, R
通讯作者：
RYLANDER, R