Neurometabolite abnormalities in simian immunodeficiency virus-infected macaques with chronic morphine administration.
Neurometabolite abnormalities in simian immunodeficiency virus-infected macaques with chronic morphine administration.
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DOI：
10.1007/s11481-010-9246-3
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发表时间：
2011-09
影响因子：
6.2
通讯作者：
Donahoe, Robert M.
中科院分区：
文献类型：
--
作者：
Cloak, Christine C.;Chang, Linda;O'Neil, Shawn P.;Ernst, Thomas M.;Anderson, Daniel C.;Donahoe, Robert M.
阿片类药物滥用会增加人类免疫缺陷病毒 (HIV) 感染的风险，而阿片类药物和艾滋病毒都可能影响免疫和神经系统。为了模拟阿片类药物和艾滋病毒在大脑中的潜在相互作用，我们对感染猿猴免疫缺陷病毒（SIV）的猕猴进行了神经代谢水平的评估，无论是否长期服用吗啡。在研究过程中，这些感染 SIV 的动物中有 58% 发展为获得性免疫缺陷综合症 (AIDS)。用质子磁共振波谱法评估了四个大脑区域的大脑提取物。与健康的非艾滋病猕猴相比，患有艾滋病的动物在所有四个脑区的 N-乙酰天冬氨酸含量较低（p≤0.05），额叶灰质总肌酸较低（p=0.03），额叶白质（p=0.003）和尾状核（p=0.002）谷氨酸较低，额叶白质肌醇较高（p=0.05）。吗啡依赖动物的壳核中肌醇水平较高（p=0.003），尤其是患有艾滋病的动物。在患有艾滋病的动物中，那些对吗啡依赖的动物额叶白质中的总肌酸含量高于那些用盐水治疗的动物（p = 0.04），而后者的肌酸含量又低于注射盐水但没有艾滋病的动物（p = 0.04），导致吗啡和艾滋病对该脑区总肌酸的影响之间存在相互作用（方差分析 p = 0.02）。这些大脑代谢物大多数与病毒计数相关，表明病毒载量或设定值较高的动物存在更严重的代谢异常。总的来说，这些发现表明，长期服用吗啡可以预防艾滋病的神经毒性作用，并强调在艾滋病中保持低病毒载量的重要性。
Opiate abuse increases the risk for human immunodeficiency virus (HIV) infection, while both opiates and HIV may impact the immune and nervous systems. To model potential interactions between opiate drugs and HIV on the brain, neurometabolite levels were evaluated in simian immunodeficiency virus (SIV)-infected macaques with or without chronic morphine administration. Over the course of the study, 58% of these SIV-infected animals progressed to acquired immune deficiency syndrome (AIDS). Brain extracts from four brain regions were evaluated with proton magnetic resonance spectroscopy. Animals with AIDS had lower N-acetyl-aspartate in all four brain regions (p≤0.05) as well as lower frontal gray matter total creatine (p=0.03), lower frontal white matter (p= 0.003) and caudate (p=0.002) glutamate, and higher frontal white matter myo-inositol (p=0.05) than the healthier non-AIDS macaques. Morphine-dependent animals had higher levels of myo-inositol in the putamen (p=0.003), especially those with AIDS. In the animals with AIDS, those with morphine dependence had higher total creatine in the frontal white matter (p=0.04) than those treated with saline, which in turn had lower creatine than saline-injected animals without AIDS (p=0.04), leading to an interaction between the effects of morphine and AIDS on total creatine in this brain region (ANOVA p=0.02). The majority of these brain metabolites correlated with viral counts indicating more severe metabolite abnormalities in animals with higher viral loads or set points. Collectively, these findings suggest that chronic morphine may protect against the neurotoxic effect of AIDS and reinforce the importance of maintaining a low viral load in AIDS.
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影响因子：
2.4
作者：
Fuller RA;Westmoreland SV;Ratai E;Greco JB;Kim JP;Lentz MR;He J;Sehgal PK;Masliah E;Halpern E;Lackner AA;González RG
通讯作者：
González RG
影响因子：
3.8
作者：
González, RG;Cheng, LL;Lackner, AA
通讯作者：
Lackner, AA
影响因子：
7.6
作者：
Pfefferbaum, A;Adalsteinsson, E;Sullivan, EV
通讯作者：
Sullivan, EV
影响因子：
3.2
作者：
Sokól, M;Przybyszewski, WM;Matlas, B
通讯作者：
Matlas, B
影响因子：
19.7
作者：
BARKER, PB;LEE, RR;MCARTHUR, JC
通讯作者：
MCARTHUR, JC