Subclinical carotid artery atherosclerosis and cognitive function in older adults.
Subclinical carotid artery atherosclerosis and cognitive function in older adults.
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DOI：
10.1186/s13195-022-00997-7
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发表时间：
2022-05-07
影响因子：
9
通讯作者：
Mack, Wendy J.
中科院分区：
文献类型：
--
作者：
Lin, Felice;Pa, Judy;Karim, Roksana;Hodis, Howard N.;Han, S. Duke;Henderson, Victor W.;St John, Jan A.;Mack, Wendy J.
关键词：
预期寿命的增加和相当多的人进入老年的综合影响将扩大美国痴呆症的流行。亚临床动脉粥样硬化先于认知功能障碍并与之相关的证据表明，年龄相关的认知功能障碍和痴呆是一个可改变的危险因素。本研究的目的是确定亚临床动脉粥样硬化（颈动脉内膜中层厚度（CIMT）测量）是否与老年人认知功能随时间的变化有关。这项研究结合了2000年至2013年期间进行的三项临床试验的纵向数据：B族维生素动脉粥样硬化干预试验（BVAIT），妇女异黄酮大豆健康（WISH）试验和早期与晚期干预试验（ELITE）。参与者从大洛杉矶地区的普通人群中招募，没有心血管疾病和糖尿病;没有指定认知或精神病排除标准。所有试验均采用相同的超声图像采集和CIMT测量标准化方案。在这些分析中使用了基线和2.5年时进行的CIMT测量。在基线和2.5年时，使用一组14项标准化认知测试评估认知功能。所有临床试验均在南加州大学洛杉矶动脉粥样硬化研究中心进行，并进行了至少2.5年的认知随访。共有308名男性和1187名女性，平均年龄为61岁，被纳入主要分析的联合纵向数据集中。在基线或2.5年时，未发现CIMT与认知功能之间存在关联。基线测量的CIMT与2.5年内评估的整体认知变化之间存在弱负相关（β（SE）=-0.056（0.028）单位/0.1 mm CIMT，95% CI-0.110，-0.001，p = 0.046）。基线CIMT与执行功能、言语记忆或视觉记忆的变化之间无相关性，在健康老年人样本中，我们的研究结果表明亚临床动脉粥样硬化与2.5年内整体认知功能变化之间存在相关性。在2.5年的时间里，纵向观察到的相关性比横截面观察到的相关性更强。当按年龄组（<65岁和≥65岁）进行分层分析时，对于年龄较大的参与者，负相关仍然具有统计学意义。颈动脉的亚临床动脉粥样硬化可能是中老年认知能力下降的一个可改变的相关因素。BVAIT，NCT 00114400。WISH，NCT 00118846。ELITE，NCT 00114517。
The combined effects of increased life expectancy and the considerable number of persons reaching old age will magnify the dementia epidemic in the USA. Demonstration that subclinical atherosclerosis precedes and is associated with cognitive impairment suggests a modifiable risk factor for age-associated cognitive impairment and dementia. The purpose of this study is to determine whether subclinical atherosclerosis as measured by carotid artery intima-media thickness (CIMT) is associated with changes in cognitive function over time in older adults. This study combined longitudinal data from three clinical trials conducted between 2000 and 2013: the B-Vitamin Atherosclerosis Intervention Trial (BVAIT), the Women’s Isoflavone Soy Health (WISH) trial, and the Early versus Late Intervention Trial with Estradiol (ELITE). Participants were recruited from the general population in the Greater Los Angeles area and were free of cardiovascular disease and diabetes; no cognitive or psychiatric exclusion criteria were specified. The same standardized protocol for ultrasound image acquisition and measurement of CIMT was used in all trials. CIMT measurements performed at baseline and 2.5 years were used in these analyses. Cognitive function was assessed at baseline and 2.5 years using a battery of 14 standardized cognitive tests. All clinical trials were conducted at the University of Southern California Atherosclerosis Research Unit, Los Angeles, and had at least 2.5 years of cognitive follow-up. A total of 308 men and 1187 women, mean age of 61 years, were included in the combined longitudinal dataset for the primary analysis. No associations were found between CIMT and cognitive function at baseline or at 2.5 years. There was a weak inverse association between CIMT measured at baseline and change in global cognition assessed over 2.5 years (β (SE) = − 0.056 (0.028) units per 0.1 mm CIMT, 95% CI − 0.110, − 0.001, p = 0.046). No associations between CIMT at baseline and changes in executive function, verbal memory, or visual memory were found. In this sample of healthy older adults, our findings suggest an association between subclinical atherosclerosis and change in global cognitive function over 2.5 years. Stronger associations were observed longitudinally over 2.5 years than cross-sectionally. When analysis was stratified by age group (<65 and ≥65 years old), the inverse association remained statistically significant for participants in the older age group. Subclinical atherosclerosis of the carotid artery may be a modifiable correlate of cognitive decline in middle and older age. BVAIT, NCT00114400. WISH, NCT00118846. ELITE, NCT00114517.
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影响因子：
8.3
作者：
Hodis HN;Mack WJ;Dustin L;Mahrer PR;Azen SP;Detrano R;Selhub J;Alaupovic P;Liu CR;Liu CH;Hwang J;Wilcox AG;Selzer RH;BVAIT Research Group
通讯作者：
BVAIT Research Group
DOI：
10.1073/pnas.1312353110
发表时间：
2013-12-10
影响因子：
11.1
作者：
Henderson, Victor W.;St John, Jan A.;Mack, Wendy J.
通讯作者：
Mack, Wendy J.
DOI：
10.1111/j.1532-5415.2006.00787.x
发表时间：
2006-06-01
影响因子：
6.3
作者：
Bo, Mario;Massaia, Massimiliano;Poli, Leone
通讯作者：
Poli, Leone
影响因子：
5
作者：
Gallagher, D;Visser, M;Heymsfield, SB
通讯作者：
Heymsfield, SB
影响因子：
9.9
作者：
Henderson, V. W.;St John, J. A.;Mack, W. J.
通讯作者：
Mack, W. J.