Human papillomavirus infection in Shenyang City, People's Republic of China: A population-based study.
Human papillomavirus infection in Shenyang City, People's Republic of China: A population-based study.
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DOI：
10.1038/sj.bjc.6603450
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发表时间：
2006-12-04
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
为了解中华人民共和国沈阳市人乳头瘤病毒（HPV）感染的流行情况及危险因素，我们对685名15-59岁的沈阳市妇女进行了访问并采集了宫颈细胞标本。使用基于GP 5 +/6+的PCR检测44种HPV类型的宫颈细胞样本中的人乳头瘤病毒DNA。总体上，人乳头瘤病毒的患病率为16.8%，在无宫颈异常的妇女中为13.6%（分别为16.6%和12.4%，以世界标准人群的年龄标准化），各年龄组的HPV患病率无显著趋势。在确定的32种类型中，高危HPV类型在所有年龄组中占主导地位，HPV 16最常见（占所有妇女的3.4%），其次是HPV 52（2.5%）和58（1.9%）。多重感染占所有感染妇女的31.3%。未婚、报告有多个性伴侣和丈夫的婚外性关系都与HPV阳性显著相关。与全球其他人群相比，沈阳的HPV患病率相对较高，这一发现提出了有关中国宫颈癌预防的重要问题，特别是考虑到预防性HPV疫苗的有效性。
To investigate the prevalence of, and risk factors for, cervical infection with human papillomavirus (HPV) in Shenyang City, People's Republic of China, we interviewed and obtained cervical cell samples from 685 women aged 15–59 years enumerated from local population lists. Human papillomavirus DNA was detected in cervical cell samples using a GP5+/6+-based PCR assay for 44 HPV types. Human papillomavirus prevalence was 16.8% overall and 13.6% among women without cervical abnormalities (16.6% and 12.4%, respectively, age-standardised to the world standard population), with no significant trends in HPV prevalence by age group. Of the 32 types identified, high-risk HPV types predominated in all age groups, HPV16 being the most common (3.4% of all women), followed by HPV52 (2.5%) and 58 (1.9%). Multiple-type infections accounted for 31.3% of all infected women. Not being married, reporting multiple sexual partners and husband's extramarital sexual relationships were all significantly associated with being HPV-positive. The disclosure of a relatively high HPV prevalence in Shenyang, in comparison with other worldwide populations, raises important questions concerning the prevention of cervical cancer in China, especially given the promising efficacy of prophylactic HPV vaccines.
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