The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Is Associated With Poor Outcome of Acute Ischemic Stroke.
The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) Score Is Associated With Poor Outcome of Acute Ischemic Stroke.
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DOI：
10.3389/fneur.2020.610318
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发表时间：
2020
影响因子：
3.4
通讯作者：
Song B
中科院分区：
文献类型：
--
作者：
Tian M;Li Y;Wang X;Tian X;Pei LL;Wang X;Zhang L;Sun W;Wu J;Sun S;Ning M;Buonanno F;Xu Y;Song B
背景：血红蛋白、白蛋白、淋巴细胞和血小板联合指数（HALP）被认为是一种反映全身炎症和营养状况的新评分。本研究旨在探讨急性缺血性脑卒中（AIS）患者HALP评分与不良预后之间的关系。方法：前瞻性纳入发病后24小时内连续的AIS患者。不良预后是在90天和1年内合并新的卒中事件（缺血性和出血性）和全因死亡。采用Cox比例风险分析HALP评分与不良结局之间的关系。结果：共纳入1337例患者。总体而言，分别有60例（4.5%）和118例（8.8%）患者在90天和1年内出现不良预后。调整相关混杂因素后，HALP评分最高五分位数的患者在90天和1年内发生不良结局的风险较低（风险比分别为0.25和0.42；95%可信区间分别为0.11-0.57和0.25 - 0.69,P <0.01）。在常规危险因素中加入HALP评分，可提高AIS患者90天内和1年内不良预后的预测（净重分类指数分别为48.38和28.95%；综合判别改善指数分别为1.51和1.51%；P均< 0.05）。结论：HALP评分升高与卒中发生后90天及1年内卒中复发及死亡风险降低相关，提示HALP评分可作为AIS的有力指标。
Background: The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP) is considered a novel score to reflect systemic inflammation and nutritional status. This study aimed to investigate the association between HALP score and poor outcome in patients with acute ischemic stroke (AIS). Methods: Consecutive AIS patients within 24 h after onset were prospectively enrolled. Poor outcome was a combination of a new stroke event (ischemic and hemorrhagic) and all-cause death within 90 days and 1 year. The association between HALP score and poor outcome was analyzed using Cox proportional hazards. Results: A total of 1,337 patients were included. Overall, 60 (4.5%) and 118 (8.8%) patients experienced poor outcome within 90 days and 1 year, respectively. Patients in the highest tertile of HALP score had a lower risk of poor outcome within 90 days and 1 year (hazard ratio: 0.25 and 0.42; 95% confidence intervals: 0.11–0.57 and 0.25–0.69, P for trend <0.01 for all) compared with those in the lowest tertile after adjusting relevant confounding factors. Adding HALP score to the conventional risk factors improved prediction of poor outcome in patients with AIS within 90 days and 1 year (net reclassification index, 48.38 and 28.95%; integrated discrimination improvement, 1.51 and 1.51%; P < 0.05 for all). Conclusions: Increased HALP score was associated with a decreased risk of recurrent stroke and death within 90 days and 1 year after stroke onset, suggesting that HALP score may serve as a powerful indicator for AIS.
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影响因子：
4.6
作者：
Peng D;Zhang CJ;Gong YQ;Hao H;Guan B;Li XS;Zhou LQ
通讯作者：
Zhou LQ
影响因子：
5.6
作者：
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通讯作者：
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通讯作者：
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影响因子：
8.3
作者：
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通讯作者：
Han, Moon-Ku