Prognostic significance of HALP (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy.
Prognostic significance of HALP (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy.
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DOI：
10.1038/s41598-018-19146-y
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发表时间：
2018-01-15
影响因子：
4.6
通讯作者：
Zhou LQ
中科院分区：
文献类型：
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作者：
Peng D;Zhang CJ;Gong YQ;Hao H;Guan B;Li XS;Zhou LQ
膀胱癌根治性膀胱切除术后的预后是不同的。我们旨在评估HALP（血红蛋白、白蛋白、淋巴细胞和血小板）对膀胱癌根治性膀胱切除术后患者预后的价值，并探索新的预后指标。本回顾性研究纳入516例膀胱癌根治性膀胱切除术后患者。中位随访时间为37个月（2 ~ 99个月）。总生存率降低的危险因素为年龄较大、TNM分期高、ASA分级高、HALP评分低。基于halp的nomogram预测准确率优于TNM分期（C- index 0.76±0.039 vs. 0.708±0.041）。结合ASA分级和HALP，我们创建了一个新的指标- HALPA评分，并发现它是降低生存率的独立危险因素（HALPA评分= 1，危险度1.624,95% CI 1.139-2.314, P = 0.007； HALPA评分= 2，危险度3.471,95% CI: 1.861-6.472, P < 0.001）。本研究确定了HALP的预后价值，并为膀胱癌根治性膀胱切除术后的HALPA评分提供了一种新的指标。
The outcome of bladder cancer after radical cystectomy is heterogeneous. We aim to evaluate the prognostic value of HALP (hemoglobin, albumin, lymphocyte and platelet) and explore novel prognostic indexes for patients with bladder cancer after radical cystectomy. In this retrospective study, 516 patients with bladder cancer after radical cystectomy were included. The median follow-up was 37 months (2 to 99 mo). Risk factors of decreased overall survival were older age, high TNM stage, high American Society of Anesthesiologists (ASA) grade and low HALP score. The predictive accuracy was better with HALP-based nomogram than TNM stage (C- index 0.76 ± 0.039 vs. 0.708 ± 0.041). By combining ASA grade and HALP, we created a novel index—HALPA score and found it an independent risk factor for decreased survival (HALPA score = 1, HR 1.624, 95% CI 1.139–2.314, P = 0.007; HALPA score = 2, HR 3.471, 95% CI: 1.861–6.472, P < 0.001).The present study identified the prognostic value of HALP and provided a novel index HALPA score for bladder cancer after radical cystectomy.
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