Magnetic resonance spectroscopic evidence of increased choline in the dorsolateral prefrontal and visual cortices in recent onset schizophrenia.
Magnetic resonance spectroscopic evidence of increased choline in the dorsolateral prefrontal and visual cortices in recent onset schizophrenia.
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DOI：
10.1016/j.neulet.2021.136410
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发表时间：
2022-01-23
影响因子：
2.5
通讯作者：
Maddock, Richard J.
中科院分区：
文献类型：
--
作者：
Smucny, Jason;Carter, Cameron S.;Maddock, Richard J.
最近发病的精神分裂症（SZ）中背外侧前额皮质（DLPFC）神经代谢谱的完整表征仍然难以捉摸。为了更好地了解该区域的神经化学如何影响 SZ 病理学，填补这一知识空白至关重要。为此，通过 3 T 磁共振波谱 (MRS) 检查近期发病的 SZ 个体 (n = 40) 和健康对照 (HC) (n = 47) 的 DLPFC N-乙酰天冬氨酸 (NAA)、肌醇、谷氨酸、胆碱和肌酸水平。还检查了作为对照区域的视觉皮层 (VC) 的代谢水平。患有 SZ 的人 DLPFC 和 VC 中的胆碱含量均显着升高，但两个区域的 NAA、肌醇、谷氨酸或肌酸没有差异。 DLPFC NAA 与 SZ 的阴性症状之间也观察到趋势水平的负相关。我们的结果表明，在最近发病的 SZ 中，前额叶和枕叶皮质中的胆碱均增加，并且 DLPFC NAA 水平可能与疾病中的阴性症状呈负相关。在最近发作的 SZ 中，观察到 DLPFC 和 VC 中含胆碱化合物的增加可能反映了膜重塑的增加，例如在响应神经炎症时激活的小胶质细胞和星形胶质细胞中发生的膜重塑。
A complete characterization of neurometabolite profiles in the dorsolateral prefrontal cortex (DLPFC) in recent onset schizophrenia (SZ) remains elusive. Filling in this knowledge gap is essential in order to better understand how the neurochemistry of this region contributes to SZ pathology. To that end, DLPFC N-acetyl aspartate (NAA), myo-inositol, glutamate, choline, and creatine levels were examined by 3 T magnetic resonance spectroscopy (MRS) in recent onset individuals with SZ (n = 40) and healthy controls (HC) (n = 47). Metabolite levels were also examined in the visual cortex (VC) as a control region. People with SZ showed significantly higher choline in both the DLPFC and VC, but no differences in NAA, myo-inositol, glutamate, or creatine in either region. A trend-level negative correlation was also observed between DLPFC NAA and negative symptoms in SZ. Our results suggest that choline is increased in both the prefrontal and occipital cortices in recent onset SZ, and that DLPFC NAA levels may be inversely related to negative symptoms in the illness. The observed increase in choline-containing compounds in both DLPFC and VC in recent onset SZ could reflect increased membrane remodeling such as occurs in activated microglia and astrocytes in response to neuroinflammation.
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