Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats.
Risk-assessment and coping strategies segregate with divergent intrinsic aerobic capacity in rats.
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DOI：
10.1038/npp.2010.144
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发表时间：
2011-01
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影响因子：
--
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中科院分区：
文献类型：
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代谢功能与个体对疾病的易感性和疾病的进展密切相关。在大鼠体内进行跑步机跑步的选择性育种已经产生了不同的高或低能力跑步者(分别为HCR和LCR)，表现出许多生理差异。到目前为止，内在有氧能力在这些大鼠的行为和应激反应中的作用还没有得到解决，这是这些研究的重点。Hcr和LCR大鼠在对新事物或在明/暗盒子中的行为的运动反应方面没有差异。相反，无论地塞帕明治疗与否，LCR大鼠在强迫游泳试验中的不动能力均高于HCR大鼠。虽然HCR和LCR大鼠对猫气味的反应减少了探索性，增加了风险评估，但HCR大鼠对猫气味表现出更强的情境制约。HCR大鼠杏仁中央核促肾上腺皮质激素释放激素表达增加，肾上腺和胸腺重量增加。在HCR和LCR大鼠中，皮质酮在明/暗转换以及对不可避免的猫气味的反应中具有可比性。然而，HCR大鼠在接受亮/暗盒子后表现出更大的皮质酮反应。这些实验表明，LCR表型与应对显著危险信号和被动应对的风险评估减少有关。相比之下，HCR大鼠表现出更自然主义的策略，它们采取积极的应对措施，对环境新鲜感和突出的危险信号做出更警惕和谨慎的反应。在此背景下，我们提出内在有氧能力是机械联系复杂的代谢性疾病和行为的中心特征。
Metabolic function is integrally related to an individual’s susceptibility to, and progression of, disease. Selective breeding for intrinsic treadmill running in rats has produced distinct lines of high or low capacity runners (HCR and LCR, respectively), that exhibit numerous physiological differences. To date the role of intrinsic aerobic capacity on behavior and stress response in these rats has not been addressed and was the focus of these studies. HCR and LCR rats did not differ in their locomotor response to novelty or behavior in the light/dark box. In contrast, immobility in the forced swim test was higher in LCR rats compared to HCR rats regardless of desipramine treatment. While both HCR and LCR rats responded to cat odor with decreased exploration and increased risk-assessment, HCR rats showed greater contextual conditioning to cat odor. HCR rats exhibited higher expression of corticotropin releasing hormone in the central nucleus of the amygdala, as well as heavier adrenal and thymus weight. Corticosterone was comparable among HCR and LCR rats at light/dark transitions, and in response to unavoidable cat odor. HCR rats, however, exhibited a greater corticosterone response following the light/dark box. These experiments show that the LCR phenotype associates with decreased risk-assessment in response to salient danger signals and passive coping. In contrast, HCR rats demonstrate a more naturalistic strategy in that they employ active coping and a more vigilant and cautious response to environmental novelty and salient danger signals. Within this context, we propose that intrinsic aerobic capacity is a central feature mechanistically linking complex metabolic disease and behavior.
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影响因子：
2.5
作者：
Buck, Bradley J.;Kerman, Ilan A.;Watson, Stanlev J.
通讯作者：
Watson, Stanlev J.
影响因子：
2.3
作者：
Gonzalez, Norberto C.;Howlett, Richard A.;Wagner, Peter D.
通讯作者：
Wagner, Peter D.
DOI：
10.1016/j.apmr.2007.09.026
发表时间：
2008-02-01
影响因子：
4.3
作者：
Hoffman, Martin D.;Hoffman, Debi Rufi
通讯作者：
Hoffman, Debi Rufi
DOI：
10.1016/j.pnpbp.2003.09.012
发表时间：
2003-12-01
影响因子：
5.6
作者：
Blanchard, DC;Griebel, G;Blanchard, RJ
通讯作者：
Blanchard, RJ
影响因子：
2.9
作者：
Burghardt, PR;Fulk, LJ;Wilson, MA
通讯作者：
Wilson, MA