Reemergence of neural crest stem cell-like states in melanoma during disease progression and treatment.
Reemergence of neural crest stem cell-like states in melanoma during disease progression and treatment.
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DOI：
10.1002/sctm.20-0351
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发表时间：
2021-04
影响因子：
6
通讯作者：
Sommer L
中科院分区：
文献类型：
--
作者：
Diener J;Sommer L
黑色素瘤是所有皮肤癌中最致命的，因为它有很高的转移潜力。近年来，靶向治疗和免疫治疗的进展使转移性疾病的治疗取得了显著进展。然而，对这些疗法的内在或获得性耐药性仍然是黑色素瘤治疗的主要障碍。黑色素瘤的疾病进展，从肿瘤起始和生长到获得侵袭性表型和转移性扩散以及获得治疗耐药性，与细胞去分化和基因调控网络劫持有关，使人联想到神经嵴(NC) -产生黑色素细胞和黑色素瘤的发育结构。本综述总结了NC干细胞（NCSC）样细胞状态参与黑色素瘤进展的实验证据，并提出了对抗与侵袭性疾病结局和耐药性相关的干细胞特征出现的新方法。
Melanoma is the deadliest of all skin cancers due to its high metastatic potential. In recent years, advances in targeted therapy and immunotherapy have contributed to a remarkable progress in the treatment of metastatic disease. However, intrinsic or acquired resistance to such therapies remains a major obstacle in melanoma treatment. Melanoma disease progression, beginning from tumor initiation and growth to acquisition of invasive phenotypes and metastatic spread and acquisition of treatment resistance, has been associated with cellular dedifferentiation and the hijacking of gene regulatory networks reminiscent of the neural crest (NC)—the developmental structure which gives rise to melanocytes and hence melanoma. This review summarizes the experimental evidence for the involvement of NC stem cell (NCSC)‐like cell states during melanoma progression and addresses novel approaches to combat the emergence of stemness characteristics that have shown to be linked with aggressive disease outcome and drug resistance.
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影响因子：
64.5
作者：
Adameyko, Igor;Lallemend, Francois;Ernfors, Patrik
通讯作者：
Ernfors, Patrik
影响因子：
4.3
作者：
Bailey, Caleb M.;Morrison, Jason A.;Kulesa, Paul M.
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Kulesa, Paul M.
影响因子：
3.2
作者：
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通讯作者：
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1146/annurev.cellbio.042308.113245
发表时间：
2010
影响因子：
11.3
作者：
Betancur P;Bronner-Fraser M;Sauka-Spengler T
通讯作者：
Sauka-Spengler T