Chromatin assembly on herpes simplex virus genomes during lytic infection.

Chromatin assembly on herpes simplex virus genomes during lytic infection.
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裂解感染期间单纯疱疹病毒基因组上的染色质组装。

DOI:
10.1016/j.bbagrm.2009.08.004
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发表时间:
2010
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Triezenberg,StevenJ
Triezenberg,StevenJ
中科院分区:
--
文献类型:
--
作者:
Lu,Xu;Triezenberg,StevenJ

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人单纯疱疹病毒HSV-1和HSV-2感染了相当大一部分人群。这两种病毒都可以在上皮细胞中进行裂解性感染,并在神经元细胞中建立终身潜伏期。大的HSV-1 DNA基因组长期以来被认为在裂解感染期间在病毒粒子颗粒内和细胞内都没有组蛋白,但在潜伏期期间被包装在抑制性染色质中。然而,最近的报道表明,许多组蛋白和非组蛋白染色体蛋白可以与病毒DNA在裂解感染,并可能影响HSV-1裂解周期中的重要事件。在这篇文章中,我们总结了这一领域的最新进展及其影响。
The human herpes simplex viruses HSV-1 and HSV-2 infect a significant portion of the human population. Both viruses can undergo lytic infection in epithelial cells and establish lifelong latency in neuronal cells. The large HSV-1 DNA genomes have long been considered to be devoid of histones both inside the virion particle and inside the cell during lytic infection, but to be packaged in repressive chromatin during latency. However, recent reports indicate that many histone and non-histone chromosomal proteins can associate with viral DNA during lytic infection and may influence important events during the HSV-1 lytic cycle. In this article, we summarize recent developments in this field and their implications.
DOI: 10.1016/j.ceb.2007.11.007
发表时间: 2008-02-01
影响因子: 7.5
作者:
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DOI: --
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