Development of the adult neurogenic niche in the hippocampus of mice.
Development of the adult neurogenic niche in the hippocampus of mice.
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DOI：
10.3389/fnana.2015.00053
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发表时间：
2015
影响因子：
2.9
通讯作者：
Kempermann G
中科院分区：
文献类型：
--
作者：
Nicola Z;Fabel K;Kempermann G
成年海马神经发生开始于何时？我们描述了海马齿状回颗粒下区（SGZ）的神经原性龛的发展。我们这样做是从成年人的情况来看的。齿状回的个体发生是复杂的，并导致一个异位的神经原性小生境，终身产生新的颗粒细胞。在胎儿和出生后早期的神经发生建立齿状回，并让位于活动依赖性的“成人”神经发生。我们使用与成人神经发生研究最相关的标志物来描述这种转变：巢蛋白，Sox 2，BLBP，GFAP，Tbr 2，Doublecortin（DCX），NeuroD 1和Prox 1。我们发现，大量的变化和局部浓缩的增殖前体细胞之间发生出生后7天（P7），在增殖的高峰附近，和P14。在P7前后，细胞的空间分布和标记物的共定位与成人的情况不同。与成年SGZ不同，标记对巢蛋白/Sox 2和放射状胶质细胞标记BLBP在胚胎发育过程中不重叠，推测表明不同类型的放射状胶质样细胞。在P7之前，门部的GFAP阳性细胞缺乏成人1型细胞所特有的径向方向。DCX，这是集中在2b型和3型祖细胞和早期有丝分裂后的神经元在成人，表现出弥漫性表达P7前。中间祖细胞标志物Tbr 2变得仅限于SGZ，但之前在颗粒细胞层（GCL）和门中发现。谱系标记NeuroD 1和Prox 1证实了这一模式。我们的结论是，成人神经发生的神经原生态位是在真正的成年之前。这可能表明，与成年神经发生在活动依赖性可塑性中的假设功能相一致，从出生后神经发生到成年神经发生的早期过渡与年轻小鼠开始变得活跃的时间相一致。
When does adult hippocampal neurogenesis begin? We describe the development of the neurogenic niche in the subgranular zone (SGZ) of the hippocampal dentate gyrus. We did so from the perspective of the situation in the adult. Ontogeny of the dentate gyrus is complex and results in an ectopic neurogenic niche that lifelong generates new granule cells. Neurogenesis during the fetal and early postnatal periods builds the dentate gyrus and gives way to activity-dependent “adult” neurogenesis. We used markers most relevant to adult neurogenesis research to describe this transition: Nestin, Sox2, BLBP, GFAP, Tbr2, Doublecortin (DCX), NeuroD1 and Prox1. We found that massive changes and a local condensation of proliferating precursor cells occurs between postnatal day 7 (P7), near the peak in proliferation, and P14. Before and around P7, the spatial distribution of cells and the co-localization of markers were distinct from the situation in the adult. Unlike the adult SGZ, the marker pair Nestin/Sox2 and the radial glial marker BLBP were not overlapping during embryonic development, presumably indicating different types of radial glia-like cells. Before P7 GFAP-positive cells in the hilus lacked the radial orientation that is characteristic of the adult type-1 cells. DCX, which is concentrated in type-2b and type-3 progenitor cells and early postmitotic neurons in the adult, showed diffuse expression before P7. Intermediate progenitor cell marker Tbr2 became restricted to the SGZ but was found in the granule cell layer (GCL) and hilus before. Lineage markers NeuroD1 and Prox1 confirmed this pattern. We conclude that the neurogenic niche of adult neurogenesis is in place well before true adulthood. This might indicate that consistent with the hypothesized function of adult neurogenesis in activity-dependent plasticity, the early transition from postnatal neurogenesis to adult neurogenesis coincides with the time, when the young mice start to become active themselves.
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DOI：
10.1523/jneurosci.4185-12.2013
发表时间：
2013-02-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hodge RD;Garcia AJ 3rd;Elsen GE;Nelson BR;Mussar KE;Reiner SL;Ramirez JM;Hevner RF
通讯作者：
Hevner RF
DOI：
10.1016/s1096-4959(01)00525-5
发表时间：
2002-05-01
影响因子：
2.2
作者：
Cayre, M;Malaterre, J;Strambi, A
通讯作者：
Strambi, A
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
16.2
作者：
Li G;Fang L;Fernández G;Pleasure SJ
通讯作者：
Pleasure SJ
影响因子：
6.2
作者：
Brunne, Bianka;Zhao, Shanting;Derouiche, Amin;Herz, Joachim;May, Petra;Frotscher, Michael;Bock, Hans H.
通讯作者：
Bock, Hans H.