Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models
Microenvironment derived from metanephros transplantation inhibits the progression of acute kidney injury in glycerol-induced rat models
复制标题
后肾移植微环境抑制甘油诱导的大鼠模型急性肾损伤的进展
DOI：
10.1080/0886022x.2019.1708393
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发表时间：
2020-01
期刊：
影响因子：
3
通讯作者：
Zhao Shengtian
中科院分区：
文献类型：
--
作者：
Li Kailin;Chen Yuan;Zhang Jianye;Guan Yong;Sun Chao;Li Xian;Xie Xiaoshuai;Zhang Denglu;Yu Xin;Liu Tongyan;Zhang Xufeng;Kong Feng;Zhao Shengtian
抽象的背景胚胎元素是哺乳动物的肾脏Anlagen，被认为是功能性整个肾脏再生的潜在来源。一些研究报告说，替诺植物植入了单侧肾切除动物c
Abstract Background Embryonic metanephros is the mammalian renal anlagen, which is considered as a potential source for the regeneration of functional whole kidneys. Some studies reported that metanephros implanted into unilateral nephrectomized animals can develop into kidney tissue. However, kidneys are nephrotoxic in renal failure patients, and whether metanephros can grow in nephrotoxic has not been reported. This study aims to investigate the growth of metanephros in acute nephrotoxic environment and analyze the therapeutic effect of metanephros microenvironment on acute kidney injury (AKI). Methods AKI was induced in 200 g Wistar rats by giving intramuscular injections of 50% glycerol (10 mL/kg) in their hind limbs. 45 rats were divided randomly into three groups (control, glycerin, and metanephros). Metanephros group was transplanted two metanephroi (embryonic day 15) into the renal capsule of AKI rats. Glycerin group was AKI rats without transplantation. Control group was untreated. Results Mature glomeruli and tubules were detected in the grafts in metanephros group, which means that metanephroi can grow into tissues with mature kidney structure under acute nephrotoxic. Then, we assessed the renal function of host rats and found that there were fewer tubular necrosis in metanephros group than glycerin group, and the serum creatinine and urea nitrogen were significantly lower in metanephros group than glycerin group. Conclusion These results suggested that embryonic metanephroi can grow into tissues with mature kidney structure under acute nephrotoxic, and the graft microenvironment was effective in inhibiting the progression of AKI, which provides a new approach for the treatment of acute renal injury.
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影响因子：
1.4
作者：
Guan Yong;Zhang Denglu;Xie Xiaoshuai;Xue Aibing;Liu Yuqiang;Zu Shulu;Zhao Shengtian;Liu Xiaoli;Zhang Xufeng;Liu Shuangde;Wang Hongwei;Li Kailin;Kong Feng;Cheng Guanghui;Sun Chao;Liu Tongyan;Zhou Chengjun;Zhao ST;Wang HW
通讯作者：
Wang HW
影响因子：
1.1
作者：
C. Vera-Donoso;X. García-Domínguez;E. Jiménez-Trigos;Luís García-Valero;J. Vicente;F. Marco-Jiménez
通讯作者：
C. Vera-Donoso;X. García-Domínguez;E. Jiménez-Trigos;Luís García-Valero;J. Vicente;F. Marco-Jiménez
影响因子：
4.1
作者：
Zhang Y;Du Y;Yu H;Zhou Y;Ge F
通讯作者：
Ge F
影响因子：
4.3
作者：
Yamanaka S;Yokoo T
通讯作者：
Yokoo T
影响因子：
3
作者：
Yuan-da Wang;Li Zhang;G. Cai;Xue‐guang Zhang;Yang Lv;Q. Hong;S. Shi;Z. Yin;Xiangdi Liu;Xiang-Mei Chen
通讯作者：
Yuan-da Wang;Li Zhang;G. Cai;Xue‐guang Zhang;Yang Lv;Q. Hong;S. Shi;Z. Yin;Xiangdi Liu;Xiang-Mei Chen