Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.
Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.
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DOI：
10.1016/j.drugalcdep.2022.109351
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发表时间：
2022-04-01
影响因子：
4.2
通讯作者：
Chambers, C. D.
中科院分区：
文献类型：
--
作者：
Bandoli, G.;Kable, J. A.;Coles, C. D.;Del Campo, M.;Suttie, M.;Chambers, C. D.
描述产前酒精暴露（PAE）的模式，并确定PAE轨迹是否与基于社区的一年级儿童样本的行为相关。使用作为胎儿酒精谱系障碍患病率研究合作的一部分收集的数据（n= 1，663），我们对怀孕和怀孕前后四个时间点报告的产前酒精使用进行了纵向聚类分析。从样本中，638名受访者报告了怀孕期间的任何酒精使用情况，并被纳入平均每日和每饮酒日最大饮酒量（最大DDD）的轨迹中。然后，我们估计与行为问题的儿童行为检查表（CBCL）和教师报告表（TRF）测量的多变量线性回归。参考组有1，025名儿童未报告PAE。选择5种轨迹描述最大DDD模式：极低/中断（n=186）、低/中断（n=111）、极低/持续（n=47）、中/高（n=245）和高（n=49）。最好描述平均每日酒精用途：非常低/停止（n=378）、非常低/持续（n=98）、低/持续（n=56）、低/停止（n=37）、中/高（n=35）和高（n=31）的六种轨迹。当评估CBCL和TRF的最大DDD轨迹时，在两个最高轨迹和非常低/持续轨迹中具有PAE的个体相对于没有PAE的儿童具有更多的行为问题，尽管大多数估计值的置信区间包括空值。以每天平均饮酒量为模型的PAE不能以任何一致的模式预测行为。在这个以社区为基础的样本中，选择的PAE轨迹与行为相关，即使在妊娠后期持续的PAE水平相对较低。
To characterize patterns of prenatal alcohol exposure (PAE), and determine whether PAE trajectories were associated with behavior from a community-based sample of first-grade children. Using data collected as part of the Collaboration of Fetal Alcohol Spectrum Disorders Prevalence study (n=1,663), we performed longitudinal cluster analysis on prenatal alcohol use reported for four time points around conception and pregnancy. From the sample, 638 respondents reported any alcohol use in pregnancy and were included in trajectories for average daily and maximum drinks per drinking day (max DDD). We then estimated the association with behavioral problems measured by the Child Behavior Checklist (CBCL) and Teacher Report Form (TRF) with multivariable linear regression. The reference group had 1,025 children with no reported PAE. Five trajectories were selected to describe max DDD patterns: very low/discontinuing (n=186), low/discontinuing (n=111), very low/continuing (n=47), med/high (n=245), and high (n=49). Six trajectories best described average daily alcohol use: very low/discontinuing (n=378), very low/continuing (n=98), low/continuing (n=56), low/discontinuing (n=37), medium/high (n=35), and high (n=31). When assessing max DDD trajectories for both the CBCL and TRF, individuals with PAE in the two highest trajectories and the very low/continuing trajectory had more behavioral problems relative to children with no PAE, although confidence intervals for most estimates included the null. PAE modeled as average drinks per day did not predict behavior in any consistent pattern. In this community-based sample, select PAE trajectories were associated with behavior, even at relatively low levels of PAE that continued later in gestation.
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影响因子：
8
作者：
Sood, B;Delaney-Black, V;Sokol, RJ
通讯作者：
Sokol, RJ
影响因子：
120.7
作者：
May, Philip A.;Chambers, Christina D.;Hoyme, H. Eugene
通讯作者：
Hoyme, H. Eugene
影响因子：
4.5
作者：
Anderson AE;Hure AJ;Kay-Lambkin FJ;Loxton DJ
通讯作者：
Loxton DJ
DOI：
10.3390/ijerph17217986
发表时间：
2020-10-30
影响因子：
--
作者：
Popova S;Lange S;Temple V;Poznyak V;Chudley AE;Burd L;Murray M;Rehm J
通讯作者：
Rehm J
影响因子：
3.2
作者：
Flak, Audrey L.;Su, Su;Cogswell, Mary E.
通讯作者：
Cogswell, Mary E.