Features of DNA Repair in the Early Stages of Mammalian Embryonic Development.

Features of DNA Repair in the Early Stages of Mammalian Embryonic Development.
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DOI:
10.3390/genes11101138
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发表时间:
2020-09-27
期刊:
影响因子:
3.5
通讯作者:
Leonova EI
Leonova EI
中科院分区:
生物学3区
文献类型:
--
作者:
Khokhlova EV;Fesenko ZS;Sopova JV;Leonova EI

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细胞修复机制负责保护基因组免受导致 DNA 损伤的内源性和外源性影响。体细胞中发生的突变会导致某些组织或器官功能障碍,而胚胎时期基因组完整性的破坏往往会导致死亡。哺乳动物胚胎对受损 DNA 做出反应并进行修复的能力,以及其对特定损伤的敏感性,目前仍不清楚。在这篇综述中,我们结合了哺乳动物胚胎植入前发育早期修复过程的不同数据。
Cell repair machinery is responsible for protecting the genome from endogenous and exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to dysfunction in certain tissues or organs, while a violation of genomic integrity during the embryonic period often leads to death. A mammalian embryo’s ability to respond to damaged DNA and repair it, as well as its sensitivity to specific lesions, is still not well understood. In this review, we combine disparate data on repair processes in the early stages of preimplantation development in mammalian embryos.
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