Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage.
Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage.
复制标题
丹酚酸B抗氧化损伤的药理作用
DOI：
10.3389/fphar.2020.572373
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发表时间：
2020
影响因子：
5.6
通讯作者：
Liu P
中科院分区：
文献类型：
--
作者：
Xiao Z;Liu W;Mu YP;Zhang H;Wang XN;Zhao CQ;Chen JM;Liu P
丹参酸B（Sali B）是丹参的主要活性成分之一，具有较强的抗氧化作用。近年来研究表明，Sal B具有抗炎、抗凋亡、抗纤维化作用，并能促进干细胞增殖和分化，对心脑血管疾病、衰老、肝纤维化等有有益作用。活性氧（ROS）包括氧自由基和含氧非自由基。活性氧（ROS）通过调节细胞增殖、存活、死亡和分化来调节炎症、免疫等，而Sal B通过提供氢原子来抑制氧自由基，通过调节抗氧化酶的表达来减少氧自由基和含氧非自由基的产生。Sal B的诸多药理作用可能与其清除和抑制ROS产生密切相关，而核因子E2相关因子2/Kelch-like ECH相关蛋白1可能是其调控抗氧化酶表达发挥抗氧化作用的核心环节。令人困惑和有趣的是，Sal B在肿瘤中表现出相反的机制。阐明Sal B的特异靶点及其调节氧化应激和能量代谢稳态的相关性，有助于进一步了解其在不同病理状态下的作用，为其进一步临床应用和新药开发提供科学依据。虽然Sal B因其广泛的药理作用而具有广阔的临床应用前景，但生物利用度低是进一步提高其体内疗效和推广临床应用的严重障碍。因此，如何提高Sal B在体内的利用度，需要多学科的共同努力。
Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza, with strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti-apoptotic, anti-fibrotic effects and can promote stem cell proliferation and differentiation, and has a beneficial effect on cardiovascular and cerebrovascular diseases, aging, and liver fibrosis. Reactive oxygen species (ROS) include oxygen free radicals and oxygen-containing non-free radicals. ROS can regulate cell proliferation, survival, death and differentiation to regulate inflammation, and immunity, while Sal B can scavenge oxygen free radicals by providing hydrogen atoms and reduce the production of oxygen free radicals and oxygen-containing non-radicals by regulating the expression of antioxidant enzymes. The many pharmacological effects of Sal B may be closely related to its elimination and inhibition of ROS generation, and Nuclear factor E2-related factor 2/Kelch-like ECH-related protein 1 may be the core link in its regulation of the expression of antioxidant enzyme to exert its antioxidant effect. What is confusing and interesting is that Sal B exhibits the opposite mechanisms in tumors. To clarify the specific target of Sal B and the correlation between its regulation of oxidative stress and energy metabolism homeostasis will help to further understand its role in different pathological conditions, and provide a scientific basis for its further clinical application and new drug development. Although Sal B has broad prospects in clinical application due to its extensive pharmacological effects, the low bioavailability is a serious obstacle to further improving its efficacy in vivo and promoting clinical application. Therefore, how to improve the availability of Sal B in vivo requires the joint efforts of many interdisciplinary subjects.
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