One week of maternal separation induces more frequent, but less predictable, maternal caregiving behaviors.
One week of maternal separation induces more frequent, but less predictable, maternal caregiving behaviors.
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DOI：
10.1002/jdn.10230
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发表时间：
2022-12
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影响因子：
--
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中科院分区：
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早期生活逆境的啮齿动物模型扰乱了母鸡和后代之间的典型互动，影响了幼崽的一生发育。照顾者互动的可预测性是环境的一个关键特征，而不可预测性与后代的行为和认知缺陷有关。在母体分离(MS)模式中，母犬分开时不能与幼崽接触，即使幼崽和母犬团聚后，母体护理也会受到影响。使用每天3.5小时的多发性硬化症方案，本研究试图比较多发性硬化症和对照饲养的母体行为的每日模式，特别是可预测性和护理的碎片化。从出生后第8天到第9天，对三个观察期(1430、2330和0830)进行了评估。测量了母体行为的频率和持续时间，包括幼犬指导的舔/梳理、弓背和被动哺乳、怀抱以及非幼犬指导的自我梳理、饲养、挖洞、筑巢和进食。巢条目的频率被解释为碎片的度量，并且从转移概率矩阵计算熵率来度量母体行为序列的可预测性。在母犬-幼崽团聚后，多发性硬化症母鼠进行了更多的哺乳和舔/梳理，更多的筑巢进入，行为序列比对照母鼠更难预测。多发性硬化症引起的护理增强是先前研究的重复，但多发性硬化症期间的不可预测性和零散的护理是一个新的发现，因为以前没有报道过多发性硬化症的这些措施。
Rodent models of early life adversity disrupt typical interactions between dams and offspring, impacting pup development over the lifespan. Predictability of caregiver interactions is a critical feature of the environment, and unpredictability is associated with behavioral and cognitive deficits in offspring. In the maternal separation (MS) paradigm, dams are not able to engage with pups while they are separated, and maternal care is impacted even after pups and dams are reunited. Using a 3.5-h daily MS protocol in rats, the present study sought to compare diurnal patterns of maternal behavior, specifically predictability and fragmentation of care, between MS- and control-reared dams. Three observation periods were assessed (1430, 2330, and 0830) between postnatal days 8–9. Frequencies and durations of maternal behaviors were measured, including pup-directed licking/grooming, arched-back and passive nursing, and carrying pups, as well as non-pup-directed self-grooming, rearing, burrowing, nest-building, and eating. The frequency of nest entries was interpreted as a measure of fragmentation, and entropy rate was calculated from transitional probability matrices to measure predictability of maternal behavioral sequences. After dam-pup reunion, MS dams engaged in more bouts of nursing and licking/grooming and more nest entries, and behavioral sequences were less predictable than control dams. MS-induced enhancement of care is a replication of previous research, but unpredictability and fragmented care during MS is a novel finding, as these measures have not been previously reported for MS.
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影响因子：
7.2
作者：
Gee DG;Cohodes EM
通讯作者：
Cohodes EM
影响因子：
3.6
作者：
Francis, D. D.;Kuhar, M. J.
通讯作者：
Kuhar, M. J.
DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
2.3
作者：
Enes-Marques, Silvia;Giusti-Paiva, Alexandre
通讯作者：
Giusti-Paiva, Alexandre
影响因子：
5
作者：
Glynn LM;Davis EP;Luby JL;Baram TZ;Sandman CA
通讯作者：
Sandman CA