Caregiving Influences on Development: A Sensitive Period for Biological Embedding of Predictability and Safety Cues.
Caregiving Influences on Development: A Sensitive Period for Biological Embedding of Predictability and Safety Cues.
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DOI：
10.1177/09637214211015673
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发表时间：
2021-10-01
影响因子：
7.2
通讯作者：
Cohodes EM
中科院分区：
文献类型：
--
作者：
Gee DG;Cohodes EM
跨物种，照顾者对后代的神经和行为发育产生强大的影响。越来越多的动物和人类研究都强调了照顾者行为的特定模式，这些模式在生命早期可能特别重要，以及将早期照顾经验与长期情感行为联系起来的神经生物学机制。在这里，我们描绘的早期敏感期在婴儿期和幼儿期的证据时，看护者的输入是可预测的，并与安全性可能成为生物嵌入通过影响皮质边缘回路参与情绪调节。我们建议，这些照顾者的信号主要皮质边缘电路接受后期阶段的具体照顾者的影响，如照顾者的外部调节儿童的情绪反应。在这一敏感时期，随着逆境的加剧，与照顾者相关的可预测性和安全性受到破坏，皮质边缘回路的加速成熟可能会缩短人类特有的可塑性和照顾者影响的长期时间。这项工作的影响，预防和干预工作的儿童暴露于早期生活的逆境。
Across species, caregivers exert a powerful influence on the neural and behavioral development of offspring. Increasingly, both animal and human research has highlighted specific patterns in caregivers’ behavior that may be especially important early in life, as well as neurobiological mechanisms linking early caregiving experiences with long-term affective behavior. Here we delineate evidence for an early sensitive period during infancy and toddlerhood when caregiver inputs that are predictable and associated with safety may become biologically embedded via influences on corticolimbic circuitry involved in emotion regulation. We propose that these caregiver signals prime corticolimbic circuitry to be receptive to later stage-specific caregiver influences, such as caregivers’ external regulation of children’s emotional reactivity. Following caregiving adversity that disrupts predictability and safety associated with caregivers during this sensitive period, accelerated maturation of corticolimbic circuitry may foreshorten the protracted period of plasticity and caregiver influence that is characteristic of humans. This work has implications for both prevention and intervention efforts for children exposed to early life adversity.
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DOI：
10.1073/pnas.1423363112
发表时间：
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影响因子：
11.1
作者：
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发表时间：
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影响因子：
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