Life on Magnet: Long-Term Exposure of Moderate Static Magnetic Fields on the Lifespan and Healthspan of Mice.
Life on Magnet: Long-Term Exposure of Moderate Static Magnetic Fields on the Lifespan and Healthspan of Mice.
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磁铁的寿命：长期暴露于小鼠的寿命和健康状态下的中等静态磁场。
DOI：
10.3390/antiox12010108
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发表时间：
2022-12-31
期刊：
影响因子：
7
通讯作者：
Zhang, Xin
中科院分区：
文献类型：
--
作者：
Fan, Yixiang;Yu, Xin;Yu, Biao;Ji, Xinmiao;Tian, Xiaofei;Song, Chao;Zhang, Xin
地球上的所有生物体都在弱地磁场（准均匀静磁场（SMF））的存在下生存和进化。与此同时，虽然中度和高度 SMF 对生物体的多个方面的影响已被研究，但长期接触 SMF 超过 1 年的报道从未报道过。在这里，我们研究了中等 SMF（从头到脚 70-220 mT）长期连续暴露（1.7 年）到两个不同 SMF 方向对健康雄性 C57BL/6 小鼠的影响。我们发现，不仅小鼠的寿命延长了，而且它们的健康状况也得到了改善。高架十字迷宫试验和旷场试验表明，SMFs可以显着提高老年小鼠的探索和运动能力。 Morris水迷宫测试表明SMF可以提高他们的空间学习能力和空间记忆。组织检查表明，SMF 对老年小鼠大脑中的氧化应激具有改善作用，细胞检测进一步证实了这一作用，表明 SMF 可以通过增加超氧化物歧化酶、过氧化氢酶和降低丙二醛水平来保护 PC12 细胞免受 D-gal 诱导的衰老。因此，我们的数据表明，由于氧化应激减少，1.7年的SMF暴露可以改善自然衰老小鼠的寿命和健康状况，这表明SMF有潜力用作辅助物理疗法，以减少衰老引起的健康风险，造福动物，甚至人类。
All living organisms on the Earth live and evolve in the presence of the weak geomagnetic field, a quasi-uniform static magnetic field (SMF). In the meantime, although the effects of moderate and high SMFs have been investigated on multiple aspects of a living organism, a long-term SMF exposure of more than 1 year has never been reported. Here, we investigated the influence of a moderate SMF (70–220 mT head-to-toe) long-term continuous exposure (1.7 years) to two different SMF directions on healthy male C57BL/6 mice. We found that not only was the lifespan of the mice prolonged, but their healthspan was also improved. The elevated plus maze test and open field test show that SMFs could significantly improve the exploratory and locomotive activities of the aged mice. The Morris water maze test shows that SMFs could improve their spatial learning ability and spatial memory. Tissue examinations reveal that SMFs have an ameliorative effect on oxidative stress in the brain of aged mice, which was reinforced by the cellular assays, showing that SMFs could protect the PC12 cells from D-gal-induced senescence by increasing superoxide dismutase, catalase, and reducing the malonaldehyde levels. Therefore, our data show that the 1.7-year SMF exposure can improve both the lifespan and healthspan of naturally aged mice due to reduced oxidative stress, which indicates that SMFs have the potential to be used as an adjuvant physical therapy to reduce the ageing-induced health risks to benefit animals, and even humans.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
4.8
作者：
de Oliveira, Marcio Augusto;Martins e Martins, Fabiana;Treister, Nathaniel S.
通讯作者：
Treister, Nathaniel S.
影响因子：
2.7
作者：
Ferrada, Pablo;Rodriguez, Sebastian;Zapata, Manuel
通讯作者：
Zapata, Manuel
影响因子：
29
作者：
Pearson KJ;Baur JA;Lewis KN;Peshkin L;Price NL;Labinskyy N;Swindell WR;Kamara D;Minor RK;Perez E;Jamieson HA;Zhang Y;Dunn SR;Sharma K;Pleshko N;Woollett LA;Csiszar A;Ikeno Y;Le Couteur D;Elliott PJ;Becker KG;Navas P;Ingram DK;Wolf NS;Ungvari Z;Sinclair DA;de Cabo R
通讯作者：
de Cabo R
影响因子：
16.6
作者：
Martin-Montalvo, Alejandro;Mercken, Evi M.;Mitchell, Sarah J.;Palacios, Hector H.;Mote, Patricia L.;Scheibye-Knudsen, Morten;Gomes, Ana P.;Ward, Theresa M.;Minor, Robin K.;Blouin, Marie-Jose;Schwab, Matthias;Pollak, Michael;Zhang, Yongqing;Yu, Yinbing;Becker, Kevin G.;Bohr, Vilhelm A.;Ingram, Donald K.;Sinclair, David A.;Wolf, Norman S.;Spindler, Stephen R.;Bernier, Michel;de Cabo, Rafael
通讯作者：
de Cabo, Rafael