Genetic Crosses and Linkage Mapping in Schistosome Parasites.
Genetic Crosses and Linkage Mapping in Schistosome Parasites.
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DOI：
10.1016/j.pt.2018.08.001
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发表时间：
2018-11
影响因子：
9.6
通讯作者：
Chevalier FD
中科院分区：
文献类型：
--
作者：
Anderson TJC;LoVerde PT;Le Clec'h W;Chevalier FD
连锁作图——利用实验性遗传杂交来检查表型性状与遗传标记的共分离——已有 100 年的历史。血吸虫寄生虫非常适合连锁图谱方法，因为可以在实验室中进行遗传杂交，产生数千个后代，并且过去 75 年的出色实验工作揭示了多种生物医学重要性状（如耐药性、宿主特异性和毒力）的可遗传遗传变异。这种方法的应用是及时的，因为曼氏血吸虫基因组组装的改进和血吸虫分子工具包的开发增加了我们将表型与基因型联系起来的能力。我们描述了血吸虫连锁图谱的当前进展和潜在的未来方向。
Linkage mapping—utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers—is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.
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影响因子：
3.3
作者：
Doyle SR;Laing R;Bartley DJ;Britton C;Chaudhry U;Gilleard JS;Holroyd N;Mable BK;Maitland K;Morrison AA;Tait A;Tracey A;Berriman M;Devaney E;Cotton JA;Sargison ND
通讯作者：
Sargison ND
影响因子：
3.8
作者：
Ballesteros C;Tritten L;O'Neill M;Burkman E;Zaky WI;Xia J;Moorhead A;Williams SA;Geary TG
通讯作者：
Geary TG
影响因子：
16.6
作者：
Adema CM;Hillier LW;Jones CS;Loker ES;Knight M;Minx P;Oliveira G;Raghavan N;Shedlock A;do Amaral LR;Arican-Goktas HD;Assis JG;Baba EH;Baron OL;Bayne CJ;Bickham-Wright U;Biggar KK;Blouin M;Bonning BC;Botka C;Bridger JM;Buckley KM;Buddenborg SK;Lima Caldeira R;Carleton J;Carvalho OS;Castillo MG;Chalmers IW;Christensens M;Clifton S;Cosseau C;Coustau C;Cripps RM;Cuesta-Astroz Y;Cummins SF;di Stephano L;Dinguirard N;Duval D;Emrich S;Feschotte C;Feyereisen R;FitzGerald P;Fronick C;Fulton L;Galinier R;Gava SG;Geusz M;Geyer KK;Giraldo-Calderón GI;de Souza Gomes M;Gordy MA;Gourbal B;Grunau C;Hanington PC;Hoffmann KF;Hughes D;Humphries J;Jackson DJ;Jannotti-Passos LK;de Jesus Jeremias W;Jobling S;Kamel B;Kapusta A;Kaur S;Koene JM;Kohn AB;Lawson D;Lawton SP;Liang D;Limpanont Y;Liu S;Lockyer AE;Lovato TL;Ludolf F;Magrini V;McManus DP;Medina M;Misra M;Mitta G;Mkoji GM;Montague MJ;Montelongo C;Moroz LL;Munoz-Torres MC;Niazi U;Noble LR;Oliveira FS;Pais FS;Papenfuss AT;Peace R;Pena JJ;Pila EA;Quelais T;Raney BJ;Rast JP;Rollinson D;Rosse IC;Rotgans B;Routledge EJ;Ryan KM;Scholte LLS;Storey KB;Swain M;Tennessen JA;Tomlinson C;Trujillo DL;Volpi EV;Walker AJ;Wang T;Wannaporn I;Warren WC;Wu XJ;Yoshino TP;Yusuf M;Zhang SM;Zhao M;Wilson RK
通讯作者：
Wilson RK
影响因子：
2.4
作者：
ANDERSON, RM;MAY, RM
通讯作者：
MAY, RM
影响因子：
1.5
作者：
Chevalier FD;Le Clec'h W;Alves de Mattos AC;LoVerde PT;Anderson TJ
通讯作者：
Anderson TJ