CEST-Dixon for human breast lesion characterization at 3 T: A preliminary study.
CEST-Dixon for human breast lesion characterization at 3 T: A preliminary study.
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DOI：
10.1002/mrm.27079
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发表时间：
2018-09
影响因子：
3.3
通讯作者：
Vinogradov E
中科院分区：
文献类型：
--
作者：
Zhang S;Seiler S;Wang X;Madhuranthakam AJ;Keupp J;Knippa EE;Lenkinski RE;Vinogradov E
CEST MRI在乳腺病变定性方面具有广阔的应用前景。然而，在乳腺CEST成像中，由于强烈的脂质信号，容易产生伪影。这项研究的目的是：1)开发和验证CEST-Dixon成像序列，用于同时进行水-脂肪分离和B0标测；2)使用CEST-Dixon方法对接受经皮活检的患者的可疑病变进行定性。梯度回波多回波Dixon采集用于创建无脂肪的CEST和B0图。该序列已在模体和活体中得到验证。对5名健康志愿者和10名患者进行扫描，比较以1、2和3.5ppm为中心的三个频率范围内的CEST对比度。将患者分为ER阴性浸润性导管癌(IDC)组(侵袭性较强)、ER阳性IDC(侵袭性较弱)组和良性组(良性组)，分析CEST对比度与病理指标(肿瘤类型、ER状态、Ki-67)的相关性。CEST-Dixon序列在仅含水的图像中显示了均匀的脂肪去除。ER阴性的IDC组织在三个频率范围内的CEST对比度均有升高的趋势，而ER阳性的IDC、良性组织和正常组织的CEST对比度均较低。ER阳性的IDC组织、良性组织和正常组织之间无显著差异。在三个频率范围中，1ppm的CEST对比度在ER阴性IDC组中较高，ER阴性IDC组与其他组之间差异最大，与Ki-67的相关性最高。乳腺CEST-Dixon成像显示有可能区分侵袭性较强的癌症和侵袭性较低的癌症。
CEST MRI for breast lesion characterization is promising. However, artifacts are prone to develop in breast CEST imaging due to strong lipid signals. The aims of the study are: 1) to develop and validate the CEST-Dixon imaging sequence for simultaneous water-fat separation and B0 mapping; 2) use the CEST-Dixon method to characterize suspicious lesions in patients undergoing percutaneous biopsy. The gradient-echo multi-echo Dixon acquisition is used to create fat-free CEST and B0 maps. The sequence has been validated in phantoms and in vivo. Five healthy volunteers and ten patients were scanned to compare the CEST contrast in three frequency ranges centered at 1, 2 and 3.5 ppm. The correlation between the CEST contrast and pathology markers (tumor type, ER status, Ki-67) was also investigated by stratifying the patients into ER-negative invasive ductal carcinoma (IDC) (more aggressive), ER-positive IDC (less aggressive) and benign groups. The CEST-Dixon sequence shows homogenous fat removal in the water-only images. The ER-negative IDC tissues display a trend to higher CEST contrast in all three frequencies ranges, while the ER-positive IDC, benign and normal tissues have lower CEST contrast. No significant differences were observed between the ER-positive IDC, benign and normal tissues. Of the three frequencies ranges, the CEST contrasts at 1 ppm are high in the ER-negative IDC group, have the largest difference between the ER-negative IDC and the other groups and have the highest correlation with Ki-67. Breast CEST-Dixon imaging shows potential to differentiate more aggressive from less aggressive cancers.
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来自Z频谱拟合的2ppm（CEST@2ppm）处的CEST信号与脑肿瘤中的肌酸分布相关。
影响因子：
2.9
作者：
Cai, Kejia;Singh, Anup;Poptani, Harish;Li, Weiguo;Yang, Shaolin;Lu, Yang;Hariharan, Hari;Zhou, Xiaohong J.;Reddy, Ravinder
通讯作者：
Reddy, Ravinder
影响因子：
--
作者：
Haroon, Saroona;Hashmi, Atif Ali;Faridi, Naveen
通讯作者：
Faridi, Naveen
影响因子：
3.5
作者：
Sun, Phillip Zhe;Longo, Dario Livio;Wu, Renhua
通讯作者：
Wu, Renhua
影响因子：
3.3
作者：
Zhou, Jinyuan;Blakeley, Jaishri O.;Hua, Jun;Kim, Mina;Laterra, John;Pomper, Martin G.;van Zijl, Peter C. M.
通讯作者：
van Zijl, Peter C. M.
影响因子：
4.4
作者：
Guo, Y;Cai, YQ;Gao, JH
通讯作者：
Gao, JH