Vitamin K status in spaceflight and ground-based models of spaceflight.
Vitamin K status in spaceflight and ground-based models of spaceflight.
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DOI：
10.1002/jbmr.289
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发表时间：
2011-05
影响因子：
6.2
通讯作者：
Smith, Scott M.
中科院分区：
文献类型：
--
作者：
Zwart, Sara R.;Booth, Sarah L.;Peterson, James W.;Wang, Zuwei;Smith, Scott M.
Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a variety of spaceflight and spaceflight analog (model) conditions, including long-duration spaceflight studies (n = 15), three bed rest studies (n = 15, 49, and 24), and a 14-day saturation dive (n= 6). In crew members who flew 2–6 months on the International Space Station, in-flight and postflight plasma phylloquinone concentrations were unchanged from the preflight mean. Consistent with this finding, urinary γ-carboxyglutamic acid (GLA), a measure of vitamin K-dependent protein turnover, did not change in response to flight. Serum undercarboxylated osteocalcin (%ucOC), a measure of vitamin K function, was generally unchanged in response to flight. Spaceflight findings were corroborated by findings of no changes in phylloquinone, urinary GLA, or %ucOC during or after bed rest in three separate bed rest studies (21–90 days in duration) or after a 14-day saturation dive. The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight. © 2011 American Society for Bone and Mineral Research.
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影响因子：
4.4
作者：
Heer, M
通讯作者：
Heer, M
DOI：
10.1249/mss.0b013e3181aa04e5
发表时间：
2009-12-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Schneider, Suzanne M.;Lee, Stuart M. C.;Hargens, Alan R.
通讯作者：
Hargens, Alan R.
影响因子：
6.2
作者：
Smith, SM;Wastney, ME;Shackelford, LC
通讯作者：
Shackelford, LC
影响因子：
4.2
作者：
Smith, SM;Davis-Street, JE;Zwart, SR
通讯作者：
Zwart, SR
影响因子：
5.8
作者：
Gundberg, CM;Nieman, SD;Rosen, H
通讯作者：
Rosen, H