Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study.
Severely low serum magnesium is associated with increased risks of positive anti-thyroglobulin antibody and hypothyroidism: A cross-sectional study.
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严重低血清镁与抗甲状腺球蛋白抗体阳性和甲状腺功能减退的风险增加相关：一项横断面研究
DOI：
10.1038/s41598-018-28362-5
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发表时间：
2018-07-02
影响因子：
4.6
通讯作者：
Zhu M
中科院分区：
文献类型：
--
作者：
Wang K;Wei H;Zhang W;Li Z;Ding L;Yu T;Tan L;Liu Y;Liu T;Wang H;Fan Y;Zhang P;Shan Z;Zhu M
碘、硒等微量元素与自身免疫性甲状腺炎及甲状腺功能密切相关。低血清镁与几种慢性疾病有关;然而，其与自身免疫性甲状腺炎和甲状腺功能的关系尚不清楚。我们调查了1,257名中国受试者的低血清镁、自身免疫性甲状腺炎和甲状腺功能之间的关系。通过问卷调查收集人口学资料，并测量血清促甲状腺激素、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体（TGAb）、游离甲状腺素、血清镁、血清碘和尿碘浓度。参与者被分为血清镁水平四分位数（≤0.55，0.551-0.85，0.851-1.15和>1.15 mmol/L）。中位血清镁水平为0.89（0.73-1.06）mmol/L;水平≤0.55 mmol/L被认为严重偏低（5.9%的受试者）。最低四分位数组TGAb阳性和超声诊断桥本甲状腺炎（HT）的风险高于镁充足组（0.851-1.15 mmol/L）（p < 0.01，OR = 2.748-3.236）。最低四分位数组发生全甲减和亚临床甲减的危险性高于镁充足组（0.851- 1.15mmol/L）（p < 0.01，OR = 4.482-4.971）。严重的低血清镁水平与TGAb阳性、HT和甲状腺功能减退的发生率增加有关。
Trace elements, such as iodine and selenium, are closely related to autoimmune thyroiditis and thyroid function. Low serum magnesium is associated with several chronic diseases; however, its associations with autoimmune thyroiditis and thyroid function are unclear. We investigated the relationships between low serum magnesium, autoimmune thyroiditis, and thyroid function in 1,257 Chinese participants. Demographic data were collected via questionnaires, and levels of serum thyroid stimulating hormone, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody (TGAb), free thyroxine, serum magnesium, serum iodine, and urinary iodine concentration were measured. Participants were divided into serum magnesium level quartiles (≤0.55, 0.551–0.85, 0.851–1.15, and >1.15 mmol/L). The median serum magnesium level was 0.89 (0.73–1.06) mmol/L; levels ≤0.55 mmol/L were considered severely low (5.9% of participants). The risks of TGAb positivity and Hashimoto thyroiditis (HT) diagnosed using ultrasonography in the lowest quartile group were higher than those in the adequate magnesium group (0.851–1.15 mmol/L) (p < 0.01, odds ratios [ORs] = 2.748–3.236). The risks of total and subclinical-only hypothyroidism in the lowest quartile group were higher than those in the adequate magnesium group (0.851–1.15 mmol/L) (p < 0.01, ORs = 4.482–4.971). Severely low serum magnesium levels are associated with an increased rate of TGAb positivity, HT, and hypothyroidism.
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影响因子：
3.9
作者：
Klatka, Maria;Grywalska, Ewelina;Partyka, Malgorzata;Charytanowicz, Malgorzata;Rolinski, Jacek
通讯作者：
Rolinski, Jacek
膳食镁摄入量与心血管疾病、2型糖尿病和全因死亡率的风险：前瞻性队列研究的剂量反应荟萃分析
影响因子：
9.3
作者：
Fang X;Wang K;Han D;He X;Wei J;Zhao L;Imam MU;Ping Z;Li Y;Xu Y;Min J;Wang F
通讯作者：
Wang F
影响因子：
3.7
作者：
Kuras Z;Yun YH;Chimote AA;Neumeier L;Conforti L
通讯作者：
Conforti L
影响因子：
64.8
作者：
Li, Feng-Yen;Chaigne-Delalande, Benjamin;Kanellopoulou, Chrysi;Davis, Jeremiah C.;Matthews, Helen F.;Douek, Daniel C.;Cohen, Jeffrey I.;Uzel, Gulbu;Su, Helen C.;Lenardo, Michael J.
通讯作者：
Lenardo, Michael J.
影响因子：
8.3
作者：
Adebamowo SN;Jiménez MC;Chiuve SE;Spiegelman D;Willett WC;Rexrode KM
通讯作者：
Rexrode KM