Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies.
Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies.
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膳食镁摄入量与心血管疾病、2型糖尿病和全因死亡率的风险：前瞻性队列研究的剂量反应荟萃分析
DOI：
10.1186/s12916-016-0742-z
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发表时间：
2016-12-08
期刊：
影响因子：
9.3
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Fang X;Wang K;Han D;He X;Wei J;Zhao L;Imam MU;Ping Z;Li Y;Xu Y;Min J;Wang F
虽然研究已经检查了膳食镁摄入量和健康结果之间的关联，但结果并不确定。在这里，我们对前瞻性队列研究进行了剂量反应荟萃分析，以调查镁摄入量与心血管疾病（CVD），2型糖尿病（T2 D）和全因死亡率风险之间的相关性。检索PubMed、EMBASE和Web of Science中包含关注结局风险估计的文章，这些文章发表于2016年5月31日。使用随机效应模型分析汇总结果。分析中包括40项前瞻性队列研究，总计超过100万名参与者。在随访期间（4 - 30年），共报告了7678例CVD、6845例冠心病（CHD）、701例心力衰竭、14,755例卒中、26,299例T2 D和10,983例死亡。增加膳食镁摄入量（每100 mg/天增量）与总CVD（RR：0.99; 95%CI，0.88-1.10）或CHD（RR：0.92; 95%CI，0.85-1.01）风险之间未观察到显著相关性。然而，镁摄入量的相同增量增加与心力衰竭风险降低22%（RR：0.78; 95%CI，0.69-0.89）和卒中风险降低7%（RR：0.93; 95%CI，0.89-0.97）相关。此外，镁摄入量每增加100毫克/天，T2 D和死亡率的综合相对风险分别为0.81（95%CI，0.77-0.86）和0.90（95%CI，0.81-0.99）。增加膳食镁摄入量与降低中风、心力衰竭、糖尿病和全因死亡率的风险相关，但与CHD或总CVD无关。这些发现支持了增加膳食镁可能对健康有益的观点。本文的在线版本（doi：10.1186/s12916-016-0742-z）包含补充材料，可供授权用户使用。
Although studies have examined the association between dietary magnesium intake and health outcome, the results are inconclusive. Here, we conducted a dose–response meta-analysis of prospective cohort studies in order to investigate the correlation between magnesium intake and the risk of cardiovascular disease (CVD), type 2 diabetes (T2D), and all-cause mortality. PubMed, EMBASE, and Web of Science were searched for articles that contained risk estimates for the outcomes of interest and were published through May 31, 2016. The pooled results were analyzed using a random-effects model. Forty prospective cohort studies totaling more than 1 million participants were included in the analysis. During the follow-up periods (ranging from 4 to 30 years), 7678 cases of CVD, 6845 cases of coronary heart disease (CHD), 701 cases of heart failure, 14,755 cases of stroke, 26,299 cases of T2D, and 10,983 deaths were reported. No significant association was observed between increasing dietary magnesium intake (per 100 mg/day increment) and the risk of total CVD (RR: 0.99; 95% CI, 0.88–1.10) or CHD (RR: 0.92; 95% CI, 0.85–1.01). However, the same incremental increase in magnesium intake was associated with a 22% reduction in the risk of heart failure (RR: 0.78; 95% CI, 0.69–0.89) and a 7% reduction in the risk of stroke (RR: 0.93; 95% CI, 0.89–0.97). Moreover, the summary relative risks of T2D and mortality per 100 mg/day increment in magnesium intake were 0.81 (95% CI, 0.77–0.86) and 0.90 (95% CI, 0.81–0.99), respectively. Increasing dietary magnesium intake is associated with a reduced risk of stroke, heart failure, diabetes, and all-cause mortality, but not CHD or total CVD. These findings support the notion that increasing dietary magnesium might provide health benefits. The online version of this article (doi:10.1186/s12916-016-0742-z) contains supplementary material, which is available to authorized users.
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影响因子：
4.3
作者：
Bhatt, Surya Prakash;Khandelwal, Pooja;Fioravanti, Gloria T.
通讯作者：
Fioravanti, Gloria T.
影响因子：
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影响因子：
2.2
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影响因子：
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Adebamowo, Sally N.;Spiegelman, Donna;Rexrode, Kathryn M.
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Rexrode, Kathryn M.