The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China.
The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China.
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中国大陆HIV-1 CRF07_BC的出现和传播动态
DOI：
10.1093/ve/veac014
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发表时间：
2022
期刊：
影响因子：
5.3
通讯作者：
Foley BT
中科院分区：
文献类型：
--
作者：
Li X;Li Y;Liu H;Trovão NS;Foley BT
1997 - 2015年间，共采集了1155份人类免疫缺陷病毒（HIV）-1 CRF 07_BC的pol基因部分序列，分布于中国大陆13个省份和风险人群[异性恋、注射吸毒者（IDU）和男男性行为者（MSM）]，以研究HIV-1 CRF 07_BC的进化、适应、时空和风险人群动态、迁移模式，和HIV-1 CRF07_BC的蛋白质结构。由于完整数据集（“full 1155”）中序列在时间、位置和风险组中的分布不均匀，因此使用了二次抽样方法。采用最大似然法和贝叶斯系统发育分析以及地理位置和危险群体的离散性状分析。为了研究HIV-1 CRF07_BC（CRF 07 -1）簇的突变，我们对该簇与其他CRF07_BC序列（“backbone_295”）进行了比较分析，并绘制了在相应蛋白质结构中观察到的突变。我们的研究结果表明，HIV-1CRF07_BC最有可能起源于1992年10月至1993年7月期间云南省的IDU [95%最高后验密度（HPD）：1989年5月至1995年8月]，云南省的IDU和广东省的MSM可能是中国大陆早期和近期传播的病毒来源。我们还发现，HIV-1 CRF 07 -1已经传播了大约20年，并继续在中国大陆和全球范围内造成局部传播。总体而言，我们的研究揭示了中国大陆HIV-1 CRF07_BC分布模式的动态。我们的研究也可能有助于制定旨在控制中国大陆和全球获得性免疫缺陷综合征的公共卫生政策。
A total of 1155 partial pol gene sequences of human immunodeficiency virus (HIV)-1 CRF07_BC were sampled between 1997 and 2015, spanning 13 provinces in Mainland China and risk groups [heterosexual, injecting drug users (IDU), and men who have sex with men (MSM)] to investigate the evolution, adaptation, spatiotemporal and risk group dynamics, migration patterns, and protein structure of HIV-1 CRF07_BC. Due to the unequal distribution of sequences across time, location, and risk group in the complete dataset (‘full1155’), subsampling methods were used. Maximum-likelihood and Bayesian phylogenetic analysis as well as discrete trait analysis of geographical location and risk group were carried out. To study mutations of a cluster of HIV-1 CRF07_BC (CRF07-1), we performed a comparative analysis of this cluster to the other CRF07_BC sequences (‘backbone_295’) and mapped the mutations observed in the respective protein structure. Our findings showed that HIV-1 CRF07_BC most likely originated among IDU in Yunnan Province between October 1992 to July 1993 [95 per cent hightest posterior density (HPD): May 1989–August 1995] and that IDU in Yunnan Province and MSM in Guangdong Province likely served as the viral sources during the early and more recent spread in Mainland China. We also revealed that HIV-1 CRF07-1 has been spreading for roughly 20 years and continues to cause local transmission in Mainland China and worldwide. Overall, our study sheds light on the dynamics of HIV-1 CRF07_BC distribution patterns in Mainland China. Our research may also be useful in formulating public health policies aimed at controlling acquired immune deficiency syndrome in Mainland China and globally.
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DOI：
10.1126/science.aaf5036
发表时间：
2016-04-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Azevedo RDSDS;Kraemer MUG;Souza R;Cunha MS;Hill SC;Thézé J;Bonsall MB;Bowden TA;Rissanen I;Rocco IM;Nogueira JS;Maeda AY;Vasami FGDS;Macedo FLL;Suzuki A;Rodrigues SG;Cruz ACR;Nunes BT;Medeiros DBA;Rodrigues DSG;Queiroz ALN;da Silva EVP;Henriques DF;da Rosa EST;de Oliveira CS;Martins LC;Vasconcelos HB;Casseb LMN;Simith DB;Messina JP;Abade L;Lourenço J;Alcantara LCJ;de Lima MM;Giovanetti M;Hay SI;de Oliveira RS;Lemos PDS;de Oliveira LF;de Lima CPS;da Silva SP;de Vasconcelos JM;Franco L;Cardoso JF;Vianez-Júnior JLDSG;Mir D;Bello G;Delatorre E;Khan K;Creatore M;Coelho GE;de Oliveira WK;Tesh R;Pybus OG;Nunes MRT;Vasconcelos PFC
通讯作者：
Vasconcelos PFC
影响因子：
4.6
作者：
Chen Y;Shen Z;Feng Y;Ruan Y;Li J;Tang S;Tang K;Liang S;Pang X;McNeil EB;Xing H;Chongsuvivatwong V;Lin M;Lan G
通讯作者：
Lan G
DOI：
10.1002/cjs.5550360302
发表时间：
2008-09-01
影响因子：
0.6
作者：
Ferreira, Marco A. R.;Suchard, Marc A.
通讯作者：
Suchard, Marc A.
影响因子：
1.5
作者：
Chin, Bum Sik;Shin, Hyoung-Shik;Smith, Davey M.
通讯作者：
Smith, Davey M.
中国上海最近感染的男男性行为者中 HIV-1 遗传多样性及其对基线 CD4 T 细胞和病毒载量的影响
影响因子：
3.7
作者：
Li X;Xue Y;Cheng H;Lin Y;Zhou L;Ning Z;Wang X;Yu X;Zhang W;Shen F;Zheng X;Gai J;Li X;Kang L;Nyambi P;Wang Y;Zhuang M;Pan Q;Zhuang X;Zhong P
通讯作者：
Zhong P