Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
复制标题
DOI：
10.5498/wjp.v12.i1.77
复制
发表时间：
2022-01-19
影响因子：
3.1
通讯作者：
O'Connor JC
中科院分区：
文献类型：
--
作者：
Porter GA;O'Connor JC
重度抑郁症是一种使人衰弱的疾病，每年影响数百万人。脑源性神经营养因子（BDNF）和炎症是抑郁症发病机制中两个重要的生物学危险因素，已受到广泛关注。许多临床和动物研究都强调了低水平的BDNF或高水平的炎症标志物与抑郁症行为症状的发展之间的关联。然而，关于BDNF和炎症之间的潜在相互作用，特别是在中枢神经系统内，知之甚少。新出现的证据表明，这些因素之间存在双向调节，对抑郁症状的发展和抗抑郁反应具有重要意义。已显示升高的炎症介质水平降低BDNF的表达，并且BDNF可能对脑内的炎症起重要的负调节作用。在神经精神疾病的背景下更充分地了解这种相互作用对于更全面地了解抑郁症的生物学发病机制和确定新的治疗机会都很重要。在这里，我们审查这两个突出的危险因素抑郁症，特别关注其相互作用的致病影响。
Major depressive disorder is a debilitating disorder affecting millions of people each year. Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention. Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression. However, less is known about potential interaction between BDNF and inflammation, particularly within the central nervous system. Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and anti-depressant response. Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF, and BDNF may play an important negative regulatory role on inflammation within the brain. Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities. Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction.
登录
查看更多内容
DOI：
10.1523/jneurosci.5818-10.2011
发表时间：
2011-03-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cortese GP;Barrientos RM;Maier SF;Patterson SL
通讯作者：
Patterson SL
影响因子：
2.9
作者：
Cho, HJ;Kim, SY;Chu, MY
通讯作者：
Chu, MY
影响因子：
3.4
作者：
Allaman, Igor;Fiumelli, Hubert;Martin, Jean-Luc
通讯作者：
Martin, Jean-Luc
DOI：
10.7759/cureus.11396
发表时间：
2020-11-09
期刊：
Cureus
影响因子：
--
作者：
Chakrapani S;Eskander N;De Los Santos LA;Omisore BA;Mostafa JA
通讯作者：
Mostafa JA
影响因子：
3.3
作者：
Barrientos, RM;Sprunger, DB;Maier, SF
通讯作者：
Maier, SF