Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort.
Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort.
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DOI：
10.1016/j.mri.2009.05.040
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发表时间：
2010-01
影响因子：
2.5
通讯作者：
Hylton, Nola
中科院分区：
文献类型：
--
作者：
Klifa, Catherine;Carballido-Gamio, Julio;Wilmes, Lisa;Laprie, Anne;Shepherd, John;Gibbs, Jessica;Fan, Bo;Noworolski, Susan;Hylton, Nola
关键词：
对35名乳腺癌高危女性进行了非对比磁共振成像(MRI)三维乳腺密度的定量测量。半自动分割工具被用来量化乳房的总体积，并在非对比MRI数据中分离纤维腺和脂肪组织的体积。MRI密度测量定义为乳房纤维腺体积与乳房总体积的比率。MRI和钼靶密度测量之间的总体相关性为R2=0.67。然而，在乳房密度较低的患者(R2=0.73)中，MRI/钼靶密度相关性高于乳房密度较高的患者(R2=0.26)。乳房X光照相密度高于25%的女性表现出非常不同的磁共振密度测量，分布在广泛的数值范围内。这些结果表明，MRI可能提供了比乳房X光检查更具代表性的乳房成分的体积测量，特别是在乳房致密的女性群体中。磁共振成像密度有可能被量化，并用于更好地评估这些人群中的乳腺癌风险。
A quantitative measure of three-dimensional breast density derived from noncontrast magnetic resonance imaging (MRI) was investigated in 35 women at high-risk for breast cancer. A semiautomatic segmentation tool was used to quantify the total volume of the breast and to separate volumes of fibroglandular and adipose tissue in noncontrast MRI data. The MRI density measure was defined as the ratio of breast fibroglandular volume over total volume of the breast. The overall correlation between MRI and mammographic density measures was R2=.67. However the MRI/mammography density correlation was higher in patients with lower breast density (R2=.73) than in patients with higher breast density (R2=.26). Women with mammographic density higher than 25% exhibited very different magnetic resonance density measures spread over a broad range of values. These results suggest that MRI may provide a volumetric measure more representative of breast composition than mammography, particularly in groups of women with dense breasts. Magnetic resonance imaging density could potentially be quantified and used for a better assessment of breast cancer risk in these populations.
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DOI：
10.1158/1055-9965.epi-07-2547
发表时间：
2008-09
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Khazen M;Warren RM;Boggis CR;Bryant EC;Reed S;Warsi I;Pointon LJ;Kwan-Lim GE;Thompson D;Eeles R;Easton D;Evans DG;Leach MO;Collaborators in the United Kingdom Medical Research Council Magnetic Resonance Imaging in Breast Screening (MARIBS) Study
通讯作者：
Collaborators in the United Kingdom Medical Research Council Magnetic Resonance Imaging in Breast Screening (MARIBS) Study
影响因子：
19.7
作者：
Kolb, TM;Lichy, J;Newhouse, JH
通讯作者：
Newhouse, JH
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R
影响因子：
5
作者：
Partridge, SC;Gibbs, JE;Hylton, NM
通讯作者：
Hylton, NM
影响因子：
8.8
作者：
Graham, SJ;Bronskill, MJ;Byng, JW;Yaffe, MJ;Boyd, NF
通讯作者：
Boyd, NF