Developing novel antifungals: lessons from G protein-coupled receptors.
Developing novel antifungals: lessons from G protein-coupled receptors.
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DOI：
10.1016/j.tips.2022.12.002
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发表时间：
2023-03
影响因子：
13.8
通讯作者：
Tate CG
中科院分区：
文献类型：
--
作者：
Velazhahan V;McCann BL;Bignell E;Tate CG
每年有多达150万人死于真菌病，但抗真菌药物种类很少，耐药性的发生率正在迅速上升。世界卫生组织最近宣布这种困境为全球卫生紧急情况，但新的抗真菌药物类别的发现仍然非常缓慢。这一过程可以通过专注于新的靶点来加速，例如G蛋白偶联受体（GPCR）样蛋白，这些蛋白具有很高的药物可能性，并且在疾病中具有明确的生物学和作用。我们讨论了最近在了解毒力生物学和酵母GPCR结构确定方面的成功，并强调了在紧急寻找新型抗真菌药物方面可能带来重大红利的新方法。
Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was recently declared by the World Health Organization as a global health emergency, but the discovery of new antifungal drug classes remains excruciatingly slow. This process could be accelerated by focusing on novel targets, such as G protein-coupled receptor (GPCR)-like proteins, that have a high likelihood of being druggable and have well-defined biology and roles in disease. We discuss recent successes in understanding the biology of virulence and in structure determination of yeast GPCRs, and highlight new approaches that might pay significant dividends in the urgent search for novel antifungal drugs.
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DOI：
10.3390/antibiotics9120877
发表时间：
2020-12-08
期刊：
Antibiotics (Basel, Switzerland)
影响因子：
--
作者：
Arastehfar A;Gabaldón T;Garcia-Rubio R;Jenks JD;Hoenigl M;Salzer HJF;Ilkit M;Lass-Flörl C;Perlin DS
通讯作者：
Perlin DS
影响因子：
64.8
作者：
Draper-Joyce CJ;Bhola R;Wang J;Bhattarai A;Nguyen ATN;Cowie-Kent I;O'Sullivan K;Chia LY;Venugopal H;Valant C;Thal DM;Wootten D;Panel N;Carlsson J;Christie MJ;White PJ;Scammells P;May LT;Sexton PM;Danev R;Miao Y;Glukhova A;Imlach WL;Christopoulos A
通讯作者：
Christopoulos A
DOI：
10.1074/jbc.r116.714980
发表时间：
2016-04-08
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Alvaro CG;Thorner J
通讯作者：
Thorner J
影响因子：
28.3
作者：
Ballou ER;Avelar GM;Childers DS;Mackie J;Bain JM;Wagener J;Kastora SL;Panea MD;Hardison SE;Walker LA;Erwig LP;Munro CA;Gow NA;Brown GD;MacCallum DM;Brown AJ
通讯作者：
Brown AJ
影响因子：
6
作者：
Bai Q;Ma J;Liu S;Xu T;Banegas-Luna AJ;Pérez-Sánchez H;Tian Y;Huang J;Liu H;Yao X
通讯作者：
Yao X