Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
复制标题
中国老年人习惯性午睡时间较长与非酒精性脂肪肝之间的关系
DOI：
10.1371/journal.pone.0105583
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Deng H
中科院分区：
文献类型：
--
作者：
Qu H;Wang H;Deng M;Wei H;Deng H
背景：白天午睡时间较长和非酒精性脂肪性肝病(NAFLD)都与糖尿病和炎症有关，但白天午睡和NAFLD之间的联系仍未被探索。目的研究中国老年人习惯性午睡时间与非酒精性脂肪肝(NAFLD)的关系，并探讨炎性细胞因子在这种关系中的作用。设计和背景2011年至2012年，我们对重庆市中国社区人群进行了一系列横断面研究。参与者在6998名年龄在40-75岁之间的参与者中，6438名符合条件的参与者被纳入第一项研究，并进行分析，以观察白天小睡时间与非酒精性脂肪肝的关系。在另一项单独的研究中，选择了80名不午睡的人和90名午睡的人来确定炎性细胞因子在这种联系中的作用。用Logistic回归模型检验NAFLD患者午睡时间的优势比(OR)。结果午睡组非酒精性脂肪肝的患病率显著高于非酒精性脂肪肝(P<；0.001)。较长的日间午睡时间与非酒精性脂肪肝呈剂量依赖关系(P趋势<；0.001)。在调整了潜在混杂因素后，与没有午睡的人相比，报告0.5-1小时午睡的OR值为1.67(95%可信区间1.13-2.46)，报告白天午睡1小时的OR值为1.49(95%可信区间1.01-2.19)(均P<；0.05)。白天午睡时间越长，IL-6和前列腺素原水平越高，分泌的卷曲相关蛋白-5水平越低，趋势均为P；0.001。在调整了IL-6、PGRN和SFRP5后，白天午睡时间与NAFLD之间的关联消失(均P>；0.05)。结论白天午睡时间越长，NAFLD的患病率越高，炎性细胞因子可能是白天午睡与NAFLD之间的重要联系。
Context Both longer habitual day napping and Non-Alcoholic Fatty Liver Disease (NAFLD) are associated with diabetes and inflammation, but the association between day napping and NAFLD remains unexplored. Objective To investigate the association between the duration of habitual day napping and NAFLD in an elderly Chinese population and to gain insight into the role of inflammatory cytokines in this association. Design and Setting We conducted a series of cross-sectional studies of the community population in Chongqing, China, from 2011 to 2012. Participants Among 6998 participants aged 40 to 75 years, 6438 eligible participants were included in the first study and analyzed to observe the association between day napping duration and NAFLD. In a separate study, 80 non-nappers and 90 nappers were selected to identify the role of inflammatory cytokines in this association. Logistic regression models were used to examine the odds ratios (ORs) of day nap duration with NAFLD. Results Day nappers had a significantly higher prevalence of NAFLD (P<0.001). Longer day napping duration was associated in a dose-dependent manner with NAFLD (P trend <0.001). After adjustment for potential confounders, the ORs were 1.67 (95% CI 1.13–2.46) for those reporting 0.5–1 h and 1.49 (95% CI 1.01–2.19) for those reporting >1 h of day napping compared with individuals who did not take day naps (all P<0.05). Longer-duration day nappers had higher levels of IL-6 and progranulin (PGRN) but lower levels of Secreted frizzled-related protein-5 (SFRP5, all P trend <0.001). After adjusting for IL-6, PGRN, and SFRP5, the association between day napping duration and NAFLD disappeared (all P>0.05). Conclusion Longer day napping duration is associated with a higher prevalence of NAFLD, and inflammatory cytokines may be an essential link between day napping and NAFLD.
登录
查看更多内容
影响因子：
4.7
作者：
Hayashi, M;Watanabe, M;Hori, T
通讯作者：
Hori, T
影响因子：
14.2
作者：
Shearer, WT;Reuben, JM;Dinges, DF
通讯作者：
Dinges, DF
影响因子：
15.1
作者：
Okun, ML;Giese, S;Coussons-Read, ME
通讯作者：
Coussons-Read, ME
影响因子：
2.4
作者：
Balkau, Beverley;Lange, Celine;Bonnet, Fabrice
通讯作者：
Bonnet, Fabrice
影响因子：
4.3
作者：
Hernandez-Alejandro, Roberto;Croome, Kris P.;Quan, Douglas
通讯作者：
Quan, Douglas