Oxidative damage and inflammation in obese diabetic Emirati subjects.
Oxidative damage and inflammation in obese diabetic Emirati subjects.
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DOI：
10.3390/nu6114872
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发表时间：
2014-11-04
期刊：
影响因子：
5.9
通讯作者：
El Essa A
中科院分区：
文献类型：
--
作者：
Gariballa S;Kosanovic M;Yasin J;El Essa A
内脏肥胖在阿拉伯人口中更为常见，与糖尿病和相关心血管疾病等发病率的关系更为密切。内脏脂肪/肥胖与糖尿病和CVD并发症之间的可能机制包括炎症和氧化应激增加;然而，阿拉伯人群的数据很少。我们的目的是确定肥胖糖尿病阿拉伯联合酋长国公民的肥胖增加是否与亚临床炎症和/或氧化应激增加有关。100名糖尿病患者参加了一项营养补充剂随机对照试验，在知情同意书后，根据人体测量和临床数据评估了他们的基线特征。我们使用世界卫生组织的数据对全身性肥胖和中心性肥胖进行分类。采集空腹血液样本用于测量抗氧化剂以及氧化损伤和炎症的标志物。我们发现，在调整了年龄、病程和糖尿病治疗后，体重指数和腰围测量的肥胖增加与C反应蛋白（CRP）升高和维生素C降低相关（p < 0.05）。尽管在男性和女性中，随着BMI和腰围的增加，炎症标志物（特别是CRP）有明显的增加趋势，抗氧化剂也有减少的趋势，但结果仅对女性有统计学意义。CRP与HDL呈负相关。总的来说，我们发现，与腰围相比，BMI低估了肥胖率，肥胖增加与炎症增加、HDL和抗氧化状态降低有关。
Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD). Possible mechanisms that link visceral fat/obesity to diabetes and CVD complications include inflammation and increased oxidative stress; however, few data are available from the Arab population. Our aim was to determine whether increased adiposity in obese diabetic United Arab Emirates citizens is associated with sub-clinical inflammation and/or increased oxidative stress. A hundred diabetic patients who were part of a randomized controlled trial of nutritional supplements had their baseline characteristics assessed from anthropometric and clinical data following informed written consent. We used WHO figures to classify general and central obesity. Fasting blood samples were collected for the measurement of antioxidants and markers of oxidative damage and inflammation. We found that increased adiposity measured by both body mass index and waist circumference was associated with increased C-reactive protein (CRP) and decreased vitamin C after adjusting for age, duration and treatment of diabetes (p < 0.05). Although there is a clear trend of increased inflammatory markers, notably CRP, and decreased antioxidants with increased BMI and waist circumference in both men and women, the results are statistically significant for women only. CRP were also inversely associated with HDL. Overall, we found that BMI underestimates the rates of obesity compared to waist circumference and that increased adiposity is associated with increased inflammation and decreased HDL and antioxidant status.
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影响因子：
5
作者：
Baik, I;Ascherio, A;Willett, WC
通讯作者：
Willett, WC
影响因子：
168.9
作者：
Yusuf, S;Hawken, S;Liu, LS
通讯作者：
Liu, LS
DOI：
10.3803/enm.2013.28.3.169
发表时间：
2013-09
期刊：
Endocrinology and metabolism (Seoul, Korea)
影响因子：
--
作者：
Barter PJ
通讯作者：
Barter PJ
影响因子：
5.1
作者：
Malik, M;Bakir, A;King, H
通讯作者：
King, H
影响因子：
2.8
作者：
POULIOT, MC;DESPRES, JP;LUPIEN, PJ
通讯作者：
LUPIEN, PJ