Drug Resistance Driven by Cancer Stem Cells and Their Niche.
Drug Resistance Driven by Cancer Stem Cells and Their Niche.
复制标题
DOI：
10.3390/ijms18122574
复制
发表时间：
2017-12-01
影响因子：
5.6
通讯作者：
Ochiya T
中科院分区：
文献类型：
--
作者：
Prieto-Vila M;Takahashi RU;Usuba W;Kohama I;Ochiya T
耐药性是癌症治疗中最大的挑战之一。肿瘤干细胞(CSCs)是肿瘤内具有自我更新、分化和致瘤性的细胞亚群，由于其具有相当大的化疗和放射耐药性，被认为是导致肿瘤治疗失败的主要原因，从而导致肿瘤复发和最终转移。CSCs位于一个特殊的微环境中，称为生态位，主要由成纤维细胞和内皮细胞、间充质细胞和免疫细胞组成，这些细胞在耐药中也发挥着关键作用。这些邻近的细胞促进CSC维持和生存所需的分子信号通路，也触发CSCs的内源性耐药。此外，像细胞外基质这样的肿瘤利基成分也在物理上保护CSCs免受治疗药物的伤害。有趣的是，CSC以双边反馈循环的方式直接为利基市场做出贡献。在这里，我们回顾了CSCs研究的最新进展，特别是它们对耐药的集体贡献，因为越来越多的研究表明，这种相互作用应该被视为治疗策略的目标。
Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem cells (CSCs), a subset of cells within the tumor with the potential for self-renewal, differentiation and tumorigenicity, are thought to be the major cause of cancer therapy failure due to their considerable chemo- and radioresistance, resulting in tumor recurrence and eventually metastasis. CSCs are situated in a specialized microenvironment termed the niche, mainly composed of fibroblasts and endothelial, mesenchymal and immune cells, which also play pivotal roles in drug resistance. These neighboring cells promote the molecular signaling pathways required for CSC maintenance and survival and also trigger endogenous drug resistance in CSCs. In addition, tumor niche components such as the extracellular matrix also physically shelter CSCs from therapeutic agents. Interestingly, CSCs contribute directly to the niche in a bilateral feedback loop manner. Here, we review the recent advances in the study of CSCs, the niche and especially their collective contribution to resistance, since increasingly studies suggest that this interaction should be considered as a target for therapeutic strategies.
登录
查看更多内容
影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
影响因子：
64.5
作者：
Acharyya S;Oskarsson T;Vanharanta S;Malladi S;Kim J;Morris PG;Manova-Todorova K;Leversha M;Hogg N;Seshan VE;Norton L;Brogi E;Massagué J
通讯作者：
Massagué J
影响因子：
23.9
作者：
Brooks MD;Burness ML;Wicha MS
通讯作者：
Wicha MS
影响因子：
20.3
作者：
Allsopp, RC;Morin, GB;Weissman, IL
通讯作者：
Weissman, IL
影响因子：
5.2
作者：
Cochrane CR;Szczepny A;Watkins DN;Cain JE
通讯作者：
Cain JE