The effect of consanguinity on coalescence times on the X chromosome.
The effect of consanguinity on coalescence times on the X chromosome.
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DOI：
10.1016/j.tpb.2021.03.004
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发表时间：
2021-08
影响因子：
1.4
通讯作者：
Rosenberg NA
中科院分区：
文献类型：
--
作者：
Cotter DJ;Severson AL;Rosenberg NA
近亲结合增加了相同的基因组片段沿着沿着不同的遗传路径遗传的频率，减少了从近亲对的后代个体中提取的等位基因对的合并时间。对于一个常染色体基因座，最近的研究表明，同一个体中两个等位基因的最近共同祖先的平均时间（TMRCA）和两个独立个体中两个等位基因的平均TMRCA都随着群体中血缘关系的增加而减少。在这里，我们将这种分析扩展到X染色体，考虑X染色体聚结倍体，男性-女性交配对的聚结模型下的时间。我们研究了四种可能的近亲交配方案，它们对常染色体的影响是相同的，但对X染色体有不同的影响：父系平行，父系交叉，母系平行，和母系交叉。在每个交配模型中，我们计算了个体内或个体间采样的X染色体等位基因的平均TMRCA。我们描述了X染色体TMRCA不同的常染色体模式下matrilateral，但不是根据父系的第一堂兄弟交配的血缘关系的影响。对于母系的第一代表亲，血缘关系在减少TMRCA方面的作用在X染色体上比在常染色体上更强，平行表亲交配的作用比交叉表亲交配的作用更强。理论计算支持该模型在理解X染色体上基因组共享模式中的实用性。
Consanguineous unions increase the frequency at which identical genomic segments are inherited along separate paths of descent, decreasing coalescence times for pairs of alleles drawn from an individual who is the offspring of a consanguineous pair. For an autosomal locus, it has recently been shown that the mean time to the most recent common ancestor (TMRCA) for two alleles in the same individual and the mean TMRCA for two alleles in two separate individuals both decrease with increasing consanguinity in a population. Here, we extend this analysis to the X chromosome, considering X-chromosomal coalescence times under a coalescent model with diploid, male–female mating pairs. We examine four possible first-cousin mating schemes that are equivalent in their effects on autosomes, but that have differing effects on the X chromosome: patrilateral-parallel, patrilateral-cross, matrilateral-parallel, and matrilateral-cross. In each mating model, we calculate mean TMRCA for X-chromosomal alleles sampled either within or between individuals. We describe a consanguinity effect on X-chromosomal TMRCA that differs from the autosomal pattern under matrilateral but not under patrilateral first-cousin mating. For matrilateral first cousins, the effect of consanguinity in reducing TMRCA is stronger on the X chromosome than on the autosomes, with an increased effect of parallel-cousin mating compared to cross-cousin mating. The theoretical computations support the utility of the model in understanding patterns of genomic sharing on the X chromosome.
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