The cerebellum and fear extinction: evidence from rodent and human studies.
The cerebellum and fear extinction: evidence from rodent and human studies.
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DOI：
10.3389/fnsys.2023.1166166
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发表时间：
2023
影响因子：
3
通讯作者：
Lawrenson, Charlotte L.
中科院分区：
文献类型：
--
作者：
Doubliez, Alice;Nio, Enzo;Senovilla-Sanz, Fernando;Spatharioti, Vasiliki;Apps, Richard;Timmann, Dagmar;Lawrenson, Charlotte L.
关键词：
小脑在情绪控制中的作用越来越受到关注，研究表明它参与了人类和啮齿动物的恐惧学习和记忆。这篇评论将集中在小脑的贡献，学习恐惧反应的灭绝。恐惧记忆的消失对于适应性行为至关重要，并且在临床上与焦虑症（如创伤后应激障碍）相关，其中认为会发生消退过程的缺陷。我们提出的证据支持小脑参与恐惧消退，从啮齿动物研究，调查分子机制和功能连接与已知的恐惧消退网络的其他大脑区域，在人类的功能磁共振成像研究。这一证据被认为与理论框架有关，即小脑通过检测预测结果和实际结果之间的错误来参与内部和外部世界内部模型的形成和更新。在恐惧条件反射的情况下，这些内部模型被认为预测了一个令人厌恶的无条件刺激（US）的发生，当令人厌恶的US在灭绝学习过程中意外地被忽略时，小脑使用预测错误来更新内部模型。人类和啮齿动物研究之间的差异突出，以帮助通知未来的工作。
The role of the cerebellum in emotional control has gained increasing interest, with studies showing it is involved in fear learning and memory in both humans and rodents. This review will focus on the contributions of the cerebellum to the extinction of learned fear responses. Extinction of fearful memories is critical for adaptive behaviour, and is clinically relevant to anxiety disorders such as post-traumatic stress disorder, in which deficits in extinction processes are thought to occur. We present evidence that supports cerebellar involvement in fear extinction, from rodent studies that investigate molecular mechanisms and functional connectivity with other brain regions of the known fear extinction network, to fMRI studies in humans. This evidence is considered in relation to the theoretical framework that the cerebellum is involved in the formation and updating of internal models of the inner and outer world by detecting errors between predicted and actual outcomes. In the case of fear conditioning, these internal models are thought to predict the occurrence of an aversive unconditioned stimulus (US), and when the aversive US is unexpectedly omitted during extinction learning the cerebellum uses prediction errors to update the internal model. Differences between human and rodent studies are highlighted to help inform future work.
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影响因子：
3.7
作者：
Dubois CJ;Liu SJ
通讯作者：
Liu SJ
DOI：
10.1073/pnas.2004258117
发表时间：
2020-07-14
影响因子：
11.1
作者：
Faul, Leonard;Stjepanovic, Daniel;LaBar, Kevin S.
通讯作者：
LaBar, Kevin S.
影响因子：
4.6
作者：
Kimpel O;Hulst T;Batsikadze G;Ernst TM;Nitsche MA;Timmann D;Gerwig M
通讯作者：
Gerwig M
影响因子：
5.7
作者：
Guell X;Gabrieli JDE;Schmahmann JD
通讯作者：
Schmahmann JD
DOI：
10.1111/ejn.12939
发表时间：
2015-09
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Harris AP;Lennen RJ;Marshall I;Jansen MA;Pernet CR;Brydges NM;Duguid IC;Holmes MC
通讯作者：
Holmes MC