Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort.
Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort.
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DOI：
10.1016/j.neuroimage.2018.01.082
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发表时间：
2018-05-15
期刊：
影响因子：
5.7
通讯作者：
Schmahmann JD
中科院分区：
文献类型：
--
作者：
Guell X;Gabrieli JDE;Schmahmann JD
描述功能地形对于不断发展的理解小脑在广泛的神经系统功能中的作用是至关重要的。我们使用人类连接组项目（n=787）的数据来分析小脑fMRI任务激活（运动、工作记忆、语言、社会和情感处理）和静息状态功能连接，这些功能连接是根据每个任务对比的Cohen’s d峰值对应的大脑皮层种子计算的。在同一参与者中，来自运动和多个非运动任务的激活，以及在同一参与者中收敛的静息状态网络的结合，揭示了人类小脑功能地形的新方面。与先前的研究一致，运动激活有两种不同的表现形式。新发现的是工作记忆、语言、社会和情感任务处理的三种不同表征，它们在很大程度上是独立于这四个认知和情感领域的。在大多数情况下，基于任务的激活和相应的静息网络相关性在识别工作记忆、语言、社会认知和情感特有的两种运动表征和三种非运动表征方面是一致的。小脑中认知和情绪任务处理中不同三重表征的明确定位和特征开辟了新的基础科学问题，如为什么会有三重表征（不同表征能实现哪些不同的功能？）和新的临床问题（不同表征的病变有什么不同的后果？）。
Delineation of functional topography is critical to the evolving understanding of the cerebellum’s role in a wide range of nervous system functions. We used data from the Human Connectome Project (n=787) to analyze cerebellar fMRI task activation (motor, working memory, language, social and emotion processing) and resting-state functional connectivity calculated from cerebral cortical seeds corresponding to the peak Cohen’s d of each task contrast. The combination of exceptional statistical power, activation from both motor and multiple non-motor tasks in the same participants, and convergent resting-state networks in the same participants revealed novel aspects of the functional topography of the human cerebellum. Consistent with prior studies there were two distinct representations of motor activation. Newly revealed were three distinct representations each for working memory, language, social, and emotional task processing that were largely separate for these four cognitive and affective domains. In most cases, the task-based activations and the corresponding resting-network correlations were congruent in identifying the two motor representations and the three non-motor representations that were unique to working memory, language, social cognition, and emotion. The definitive localization and characterization of distinct triple representations for cognition and emotion task processing in the cerebellum opens up new basic science questions as to why there are triple representations (what different functions are enabled by the different representations?) and new clinical questions (what are the differing consequences of lesions to the different representations?).
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影响因子：
5.7
作者：
Binder JR;Gross WL;Allendorfer JB;Bonilha L;Chapin J;Edwards JC;Grabowski TJ;Langfitt JT;Loring DW;Lowe MJ;Koenig K;Morgan PS;Ojemann JG;Rorden C;Szaflarski JP;Tivarus ME;Weaver KE
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Weaver KE
影响因子：
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Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
通讯作者：
Sokolov, Arseny A.
影响因子：
5.7
作者：
Baumann, Oliver;Mattingley, Jason B.
通讯作者：
Mattingley, Jason B.
影响因子：
6
作者：
Garrard, P.;Martin, N. H.;Cipolotti, L.
通讯作者：
Cipolotti, L.
影响因子：
2.5
作者：
BROCHU, G;MALER, L;HAWKES, R
通讯作者：
HAWKES, R